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Antimicrobial effect of medical adhesive composed of aldehyded dextran and ε-Poly(L-Lysine).

Title
 Antimicrobial effect of medical adhesive composed of aldehyded dextran and ε-Poly(L-Lysine).
Authors
 Lee, Jeong-Hyun; Hye-Lee Kim; Jong-Chul Park; Suong-Hyu Hyon; Hideaki Taguchi; Mi Hee Lee
Issue Date
2011
Journal Title
 Journal of Microbiology and Biotechnology
ISSN
 1017-7825
Citation
 Journal of Microbiology and Biotechnology, Vol.21(11) : 1199~1202, 2011
Abstract
Infection of surgical wounds is a severe problem. Conventional tissue reattachment methods have limits of incomplete sealing and high susceptibility to infection. Medical adhesives have several advantages over traditional tissue reattachment techniques, but still have drawbacks, such as the probability of infection, low adhesive strength, and high cytotoxicity. Recently, a new medical adhesive (new-adhesive) with high adhesive strength and low cytotoxicity, composed of aldehyded dextran and ε-poly(L-lysine), was developed. The antimicrobial activity of the new-adhesive was assayed using agar media and porcine skin. In the agar diffusion method, inoculated microorganisms that contacted the new-adhesive were inactivated, but this was not dependent on the amount of new-adhesive. Similar to the agar media results, the topical antimicrobial effect of new-adhesive was confirmed using a porcine skin antimicrobial assay, and the effect was not due to physical blocking based on comparison with the group whose wounds were wrapped.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94272
DOI
10.4014/jmb.1105.05054
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Medical Engineering
Yonsei Authors
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