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Antimicrobial effect of medical adhesive composed of aldehyded dextran and ε-Poly(L-Lysine).

Authors
 Lee, Jeong-Hyun  ;  Hye-Lee Kim  ;  Mi Hee Lee  ;  Hideaki Taguchi  ;  Suong-Hyu Hyon  ;  Jong-Chul Park 
Citation
 JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Vol.21(11) : 1199-1202, 2011 
Journal Title
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
ISSN
 1017-7825 
Issue Date
2011
MeSH
Animals ; Anti-Infective Agents/pharmacology* ; Bacteria/drug effects ; Candida albicans/drug effects ; Dextrans/pharmacology* ; Microbial Sensitivity Tests/methods ; Microbial Viability/drug effects ; Polylysine/pharmacology* ; Skin/microbiology ; Swine ; Tissue Adhesives/pharmacology*
Keywords
Medical adhesive, ε-poly(L-lysine) ; aldehyded dextran ; antimicrobial effect
Abstract
Infection of surgical wounds is a severe problem. Conventional tissue reattachment methods have limits of incomplete sealing and high susceptibility to infection. Medical adhesives have several advantages over traditional tissue reattachment techniques, but still have drawbacks, such as the probability of infection, low adhesive strength, and high cytotoxicity. Recently, a new medical adhesive (new-adhesive) with high adhesive strength and low cytotoxicity, composed of aldehyded dextran and ε-poly(L-lysine), was developed. The antimicrobial activity of the new-adhesive was assayed using agar media and porcine skin. In the agar diffusion method, inoculated microorganisms that contacted the new-adhesive were inactivated, but this was not dependent on the amount of new-adhesive. Similar to the agar media results, the topical antimicrobial effect of new-adhesive was confirmed using a porcine skin antimicrobial assay, and the effect was not due to physical blocking based on comparison with the group whose wounds were wrapped.
Files in This Item:
T201103395.pdf Download
DOI
10.4014/jmb.1105.05054
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Lee(김혜리)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
Lee, Jeong Hyun(이정현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94272
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