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A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery.

Authors
 Bo Reum Lee ; Kyung Taek Oh ; Eun Seong Lee ; Yu Seok Youn ; So Young Park ; Hye Jung Baik ; Young Taik Oh 
Citation
 Chemical communications (London. 1996), Vol.47(13) : 3852~3854, 2011 
Journal Title
 Chemical communications (London. 1996) 
ISSN
 1359-7345 
Issue Date
2011
Abstract
We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94259
DOI
10.1039/c0cc03590d
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://pubs.rsc.org/en/Content/ArticleLanding/2011/CC/c0cc03590d
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