A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery.
Bo Reum Lee ; Kyung Taek Oh ; Eun Seong Lee ; Yu Seok Youn ; So Young Park ; Hye Jung Baik ; Young Taik Oh
Chemical communications (London. 1996), Vol.47(13) : 3852~3854, 2011
Chemical communications (London. 1996)
We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.