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Diffuse microcalcifications only of the thyroid gland seen on ultrasound: clinical implication and diagnostic approach.

Authors
 Jung Hyun Yoon ; Eun-Kyung Kim ; Jin Young Kwak ; Hee Jung Moon ; Eun Ju Son 
Citation
 Annals of Surgical Oncology, Vol.18(10) : 2899~2906, 2011 
Journal Title
 Annals of Surgical Oncology 
ISSN
 1068-9265 
Issue Date
2011
Abstract
BACKGROUND: To evaluate the clinical implications and diagnostic approach of lesions showing only diffuse microcalcifications on thyroid ultrasound (US). METHODS: From January 2004 to January 2011, a total of 31 patients had lesions showing diffuse microcalcifications alone on thyroid US. Among them, 26 patients (M:F ratio 4:22; mean age 37.5 years, range 15-56 years) who had underwent US-guided fine-needle aspiration biopsy (US-FNAB), subsequent surgery, or follow-up US after 1 year after initial US-FNAB were included. Histopathologic results from surgery or US-FNAB were considered as standard reference. Clinical and US features were compared to standard reference. RESULTS: Of the disease of 26 patients, 16 (61.5%) were diagnosed as malignancy and 10 (38.5%) as benign. Seventeen (65.4%) of the 26 patients included were diagnosed as having Hashimoto thyroiditis (HT) on a clinical basis. Eight (80.0%) of the 10 benign lesions were diagnosed as benign on initial US-FNAB, and the remaining 2 lesions (20.0%) were nondiagnostic. All malignant lesions were diagnosed as suspicious for papillary thyroid carcinoma (PTC) or PTC by US-FNAB. Of the US features, presence of pathologic lymph nodes were significantly higher in malignant disease compared to benign findings, 10 (62.5%) to 0 (0.0%) (P = 0.003). CONCLUSIONS: Diffuse microcalcifications only lesions of the thyroid show high prevalence of PTC and lymphocytic thyroiditis. US-FNAB shows an acceptable performance in lesions showing microcalcifications only on thyroid US.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94238
DOI
10.1245/s10434-011-1717-0
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
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Link
 http://link.springer.com/article/10.1245%2Fs10434-011-1717-0
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