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Predictive clinical parameters for the therapeutic efficacy of sitagliptin in korean type 2 diabetes mellitus

Title
 Predictive clinical parameters for the therapeutic efficacy of sitagliptin in korean type 2 diabetes mellitus
Authors
 Soon Ae Kim; Woo Ho Shim; Kyung Rae Kim; Chul Woo Ahn; Jong Suk Park; Min Ho Cho; Ji Sun Nam; Jeong Seon Yoo; Eun Sook Kim; Sun Hee Beom; Young Mi Lee; Eun Hae Lee
Issue Date
2011
Journal Title
 Diabetes & Metabolism Journal
ISSN
 2233-6079
Citation
 Diabetes & Metabolism Journal, Vol.35(2) : 159~165, 2011
Abstract
BACKGROUND: Sitagliptin is a highly selective dipeptidyl peptide-4 (DPP-4) inhibitor that increases blood levels of active glucagon-like peptide (GLP)-1 and glucose-dependent insulinotrophic polypeptide (GIP), resulting in increased insulin secretion. While studies conducted in other countries have indicated the efficacy and safety of using sitagliptin to treat type 2 diabetes mellitus (T2DM), its predictors of effects to sitagliptin are not well understood. Therefore, we evaluated the predictive clinical parameters for the therapeutic benefits of sitagliptin when added to an ongoing metformin or sulfonylurea therapy in Korean T2DM subjects. METHODS: We obtained data from 251 Korean T2DM subjects who had recently started taking sitagliptin as add-on therapy. Exclusion criteria included any insulin use. Changes in HbA1c (ΔHbA1c) and fasting plasma glucose (ΔFPG) were assessed by comparing baseline levels prior to sitagliptin administration to levels 12 and 24 weeks after treatment. Responders were defined as subjects who experienced decrease from baseline of >10% in ΔHbA1c or >20% in ΔFPG levels at 24 weeks. RESULTS: We classified 81% of the subjects (204 out of 251) as responders. The responder group had a lower mean body mass index (23.70±2.40 vs. 26.00±2.26, P≤0.01) and were younger (58.83±11.57 years vs. 62.87±12.09 years, P=0.03) than the non-responder group. CONCLUSION: In Korean T2DM subjects, sitagliptin responders had lower body mass index and were younger compared to non-responders.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93876
DOI
10.4093/dmj.2011.35.2.159
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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