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Predictive factors for indeterminate result on the QuantiFERON test in an intermediate tuberculosis-burden country

Authors
 구남수 ; 김준명 ; 김창오 ; 김현숙 ; 백지현 ; 송영구 ; 정수진 ; 진성준 ; 최준용 ; 한상훈 
Citation
 Journal of Infection, Vol.62(5) : 347~354, 2011 
Journal Title
 Journal of Infection 
ISSN
 0163-4453 
Issue Date
2011
Abstract
OBJECTIVES: The QuantiFERON-TB Gold In-Tube (QFT-G IT) test is based on the cellular immune response, and this assay can result in indeterminate results for the diagnosis of tuberculosis. The occurrence of indeterminate results may decrease the clinical usefulness of this test. Therefore, we investigated possible predictive factors that can influence the occurrence of indeterminate results from the QFT-G IT test. METHODS: We conducted a case-control study with 162 case patients who had indeterminate results from a QFT-G IT test at a tertiary hospital in South Korea, from September 2006 to September 2009. RESULTS: Of the 1276 patients, 162 (12.7%) cases that underwent QFT-G IT testing were reported as indeterminate results. Severe lymphopenia (odds ratio [OR] = 8.839; p < 0.001), chronic renal disease (OR = 2.838; p = 0.007), autoimmune disease (OR = 2.527; p = 0.017) and chronic lung disease (OR = 3.169; p = 0.007) were independent predictive factors for indeterminate results from a QFT-G IT test. CONCLUSION: The patients with lower lymphocyte counts or immunosuppressive conditions showed a higher probability of indeterminate results from the QFT-G IT test. Careful attention to the pre-analytical conditions may be able to minimize this proportion.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93336
DOI
10.1016/j.jinf.2011.03.004
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0163445311000697
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