Cited 0 times in

Drug-loaded porous spherical hydroxyapatite granules for bone regeneration

Title
 Drug-loaded porous spherical hydroxyapatite granules for bone regeneration 
Authors
 Min-Ho Hong ; Jun-Sik Son ; Yong-Keun Lee ; Daniel S. Oh ; Myungho Han ; Kwang-Mahn Kim 
Issue Date
2011
Journal Title
 Journal of Materials Science-Materials in Medicine 
ISSN
 0957-4530 
Citation
 Journal of Materials Science-Materials in Medicine, Vol.22(2) : 349~355, 2011 
Abstract
Porous spherical hydroxyapatite (HAp) granules, which are not only can be used for bone void filler, but also drug delivery systems, were prepared using a liquid nitrogen method. Various pore and channel structures of spherical granules were obtained by adjusting the ratio of water to HAp powder and the amount of sodium chloride (NaCl). By using the water to powder ratio at 2.0 ml/g and the amount of NaCl at 15 wt% by powder, the spherical granules have optimal pore volume, micro-channel structure and strength to handle as well as the ability to work as a drug delivery system. When the NaCl content was 15 wt%, the micro-channel structure was changed, but the pore volume was maintained. For the drug release test, dexamathasone (Dex) was loaded as a model drug on the prepared HAp granules by the immersion method, and the drug release behavior was curved by a UV/vis spectrophotometer. As a result, different drug release behavior was observed according to micro-channel structural differences. Therefore, it was concluded that the NACl could be applied as the pore and micro-channel structure control agent. Porous spherical HAp granules, which were fabricated by a liquid nitrogen method, show potential as bone void filler with the ability of controlled drug release
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92946
DOI
10.1007/s10856-010-4197-z
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Dental Engineering
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://link.springer.com/article/10.1007%2Fs10856-010-4197-z
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse