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Plasma ceruloplasmin as a biomarker for obesity: a proteomic approach.

Authors
 Oh Yoen Kim ; Min-Jeong Shin ; Ji Hyung Chung ; Jiyoung Moon 
Citation
 Clinical Biochemistry, Vol.44(5-6) : 351~356, 2011 
Journal Title
 Clinical Biochemistry 
ISSN
 0009-9120 
Issue Date
2011
Abstract
OBJECTIVES: This study aimed to investigate new biomarkers of obesity particularly in relation with inflammation-associated proteins using protein differential display techniques. DESIGN AND METHODS: Comparison of protein expression in plasma between non-obese (n=109, body mass index, BMI<25kg/m(2)) and obese (n=32, BMI≥25kg/m(2)) groups was carried out using two-dimensional gel electrophoresis (2-DE) analysis. ELISA was also performed for validation. RESULTS: Among six differentially expressed protein spots, ceruloplasmin (Cp) and fibrinogen were over-expressed in obese group. Plasma Cp levels were significantly higher in obese group than non-obese group (34.0 ± 8.6 vs. 41.3 ± 12.7mg/dL, p<0.001) and positively correlated with age (r=0.253, p<0.005), BMI (r=0.265, p<0.001) and hsCRP (r=0.385, p<0.001). In stepwise multiple linear regression analysis, plasma Cp along with hsCRP were found predictors for obesity (adjusted β-coefficient=0.266, p<0.01). CONCLUSION: Elevated plasma Cp levels were significantly associated with obesity, which may be suggested to be a marker of obesity
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92731
DOI
10.1016/j.clinbiochem.2011.01.014
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Cardiovascular Product Evaluation Center
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0009912011000427
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