Cited 47 times in
Plasma ceruloplasmin as a biomarker for obesity: a proteomic approach.
DC Field | Value | Language |
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dc.contributor.author | 정지형 | - |
dc.date.accessioned | 2014-12-20T16:26:47Z | - |
dc.date.available | 2014-12-20T16:26:47Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92731 | - |
dc.description.abstract | OBJECTIVES: This study aimed to investigate new biomarkers of obesity particularly in relation with inflammation-associated proteins using protein differential display techniques. DESIGN AND METHODS: Comparison of protein expression in plasma between non-obese (n=109, body mass index, BMI<25kg/m(2)) and obese (n=32, BMI≥25kg/m(2)) groups was carried out using two-dimensional gel electrophoresis (2-DE) analysis. ELISA was also performed for validation. RESULTS: Among six differentially expressed protein spots, ceruloplasmin (Cp) and fibrinogen were over-expressed in obese group. Plasma Cp levels were significantly higher in obese group than non-obese group (34.0 ± 8.6 vs. 41.3 ± 12.7mg/dL, p<0.001) and positively correlated with age (r=0.253, p<0.005), BMI (r=0.265, p<0.001) and hsCRP (r=0.385, p<0.001). In stepwise multiple linear regression analysis, plasma Cp along with hsCRP were found predictors for obesity (adjusted β-coefficient=0.266, p<0.01). CONCLUSION: Elevated plasma Cp levels were significantly associated with obesity, which may be suggested to be a marker of obesity | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 351~356 | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers/blood* | - |
dc.subject.MESH | Ceruloplasmin/metabolism* | - |
dc.subject.MESH | Electrophoresis, Gel, Two-Dimensional | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/blood* | - |
dc.subject.MESH | Proteomics* | - |
dc.subject.MESH | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | - |
dc.title | Plasma ceruloplasmin as a biomarker for obesity: a proteomic approach. | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Research Institute for Cerebral & Cardiovascular Diseases (심혈관제품유효성평가센터) | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Min-Jeong Shin | - |
dc.contributor.googleauthor | Jiyoung Moon | - |
dc.contributor.googleauthor | Ji Hyung Chung | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2011.01.014 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03739 | - |
dc.relation.journalcode | J00561 | - |
dc.identifier.eissn | 1873-2933 | - |
dc.identifier.pmid | 21291874 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009912011000427 | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Two-dimensional gel electrophoresis | - |
dc.subject.keyword | Ceruloplasmin | - |
dc.subject.keyword | Biomarker | - |
dc.subject.keyword | Proteomics | - |
dc.contributor.alternativeName | Chung, Ji Hyung | - |
dc.contributor.affiliatedAuthor | Chung, Ji Hyung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5-6 | - |
dc.citation.startPage | 351 | - |
dc.citation.endPage | 356 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, Vol.44(5-6) : 351-356, 2011 | - |
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