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Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men

Authors
 Ji Young Kim ; Jean Kyung Paik ; Jong Ho Lee ; Yangsoo Jang ; Jin Hee Lee ; Hae Won Park ; Oh Yoen Kim 
Citation
 Atherosclerosis, Vol.215(1) : 189~195, 2011 
Journal Title
 Atherosclerosis 
ISSN
 0021-9150 
Issue Date
2011
Abstract
OBJECTIVE: The objective was to determine the effects of lycopene supplementation on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT) and oxidative stress. METHODS: Healthy men (n=126) were randomized to receive placebo (n=38), 6 mg (n=41), or 15 mg (n=37) lycopene daily for 8-week. RESULTS: Serum lycopene increased in a dose-dependent manner after 8-week supplementation (P<0.001). The 15 mg/day group had greater increase in plasma SOD activity (P=0.014) and reduction in lymphocyte DNA comet tail length (P=0.042) than the placebo group. Intragroup comparison revealed a 23% increase in RH-PAT index from baseline (1.45±0.09 vs. 1.79±0.12; P=0.032) in the 15 mg/day group after 8-week. hs-CRP, systolic blood pressure, sICAM-1 and sVCAM-1 significantly decreased, and β-carotene and LDL-particle size significantly increased only in the 15 mg/day group. Interestingly, the beneficial effect of lycopene supplementation on endothelial function (i.e., RH-PAT and sVCAM-1) were remarkable in subjects with relatively impaired endothelial cell function at initial level. Changes in RH-PAT index correlated with SOD activity (r=0.234, P=0.017) especially in the 15 mg lycopene/day group (r=0.485, P=0.003), lymphocyte DNA comet tail moment (r=-0.318, P=0.001), and hs-CRP (r=-0.238, P=0.011). In addition, changes in lycopene correlated with hs-CRP (r=-0.230, P=0.016) and SOD activity (r=0.205, P=0.037). CONCLUSION: An increase in serum lycopene after supplementation can reduce oxidative stress which may play a role in endothelial function.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92583
DOI
10.1016/j.atherosclerosis.2010.11.036
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0021915010009755
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