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Neurorestoration induced by mesenchymal stem cells: potential therapeutic mechanisms for clinical trials

Title
 Neurorestoration induced by mesenchymal stem cells: potential therapeutic mechanisms for clinical trials 
Authors
 Jung Hwa Seo ; Sung-Rae Cho 
Issue Date
2012
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Citation
 Yonsei Medical Journal, Vol.53(6) : 1059~1067, 2012 
Abstract
Stem cells are emerging as therapeutic candidates in a variety of diseases because of their multipotent capacities. Among these, mesenchymal stem cells (MSCs) derived from bone marrow, umbilical cord blood or adipose tissue, comprise a population of cells that exhibit extensive proliferative potential and retain the ability to differentiate into multiple tissue-specific lineage cells including osteoblasts, chondrocytes, and adipocytes. MSCs have also been shown to enhance neurological recovery, although the therapeutic effects seem to be derived from an indirect paracrine effect rather than direct cell replacement. MSCs secrete neurotrophic factors, promote endogenous neurogenesis and angiogenesis, encourage synaptic connection and remyelination of damaged axons, decrease apoptosis, and regulate inflammation primarily through paracrine actions. Accordingly, MSCs may prevail as a promising cell source for cell-based therapy in neurological diseases.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92129
DOI
10.3349/ymj.2012.53.6.1059
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Rehabilitation Medicine
Yonsei Authors
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