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Phagocytosis and endocytosis of silver nanoparticles induce interleukin-8 production in human macrophages. Kim S, Choi IH.

Authors
 최인홍 
Citation
 Yonsei Medical Journal, Vol.53(3) : 654~657, 2012 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2012
Abstract
Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-treated with inhibitors to phagocytosis, caveolin-mediated endocytosis, or clathrin-mediated endocytosis, prior to exposure to silver nanoparticles, Interleukin-8 (IL-8) production was inhibited. Although cell death was not reduced, the inflammatory response by macrophages was compromised by phagocytosis and endocytosis inhibitors.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92083
DOI
10.3349/ymj.2012.53.3.654
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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