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Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia

Title
Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia
Authors
Ku, Nam Su;Kim, Hye-won;Choi, Jun Yong;Kim, June Myung;Song, Young Goo;Kim, Chang Oh;Han, Sang Hoon;Jeong, Su Jin;Kim, Sun Bean;Ahn, Jin Young;Oh, Dong Hyun;Song, Je Eun;Kim, Min Hyung;Kim, Yong Chan;Oh, Hyung Jung
Issue Date
2012
Journal Title
Shock
ISSN
1073-2322
Citation
Shock, Vol.38(2) : 123~127, 2012
Abstract
Red blood cell distribution width (RDW) is known to be a predictor of severe morbidity and mortality in some chronic diseases such as congestive heart failure. However, to our knowledge, little is known about RDW as a predictor of mortality in patients with Gram-negative bacteremia, a major nosocomial cause of intra-abdominal infections, urinary tract infections, and primary bacteremia. Therefore, we investigated whether RDW is an independent predictor of mortality in patients with Gram-negative bacteremia. Clinical characteristics, laboratory parameters, and outcomes of 161 patients with Gram-negative bacteremia from November 2010 to March 2011 diagnosed at Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, were retrospectively analyzed. The main outcome measure was 28-day all-cause mortality. The 28-day mortality rate was significantly higher in the increased RDW group compared with the normal RDW group (P < 0.001). According to multivariate Cox proportional hazard analysis, RDW levels at the onset of bacteremia (per 1% increase, P = 0.036), the Charlson index (per 1-point increase, P < 0.001), and the Sequential Organ Failure Assessment score (per 1-point increase, P = 0.001) were independent risk factors for 28-day mortality. Moreover, the nonsurvivor group had significantly higher RDW levels 72 h after the onset of bacteremia than did the survivor group (P = 0.001). In addition, the area under the curve of RDW at the onset of bacteremia, the 72-h RDW, and the Sequential Organ Failure Assessment score for 28-day mortality were 0.764 (P = 0.001), 0.802 (P < 0.001), and 0.703 (P = 0.008), respectively. Red blood cell distribution width at the onset of bacteremia was an independent predictor of mortality in patients with Gram-negative bacteremia. Also, 72-h RDW could be a predictor for all-cause mortality in patients with Gram-negative bacteremia.
URI
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00024382-201208000-00002&LSLINK=80&D=ovft

http://ir.ymlib.yonsei.ac.kr/handle/22282913/91849
DOI
10.1097/SHK.0b013e31825e2a85
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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