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Clinical characteristics of acute hepatitis A complicated by acute kidney injury

Authors
 Jung Hwan Yu ; Ja Kyung Kim ; Kwan Sik Lee ; Chae Yoon Chon ; Kwang-Hyub Han ; Sang Hoon Ahn ; Do Young Kim ; Yong Han Paik ; Jun yong Park 
Citation
 Scandinavian Journal of Infectious Diseases, Vol.44(2) : 144~148, 2012 
Journal Title
 Scandinavian Journal of Infectious Diseases 
ISSN
 0036-5548 
Issue Date
2012
Abstract
BACKGROUND: The incidence of acute viral hepatitis A (AHA) in Korea is increasing rapidly. Additionally, we are encountering more cases with acute kidney injury (AKI), which was once regarded as a rare complication of AHA. Thus, we investigated recent aspects of the incidence and clinical characteristics of AHA complicated by AKI. METHODS: Patients diagnosed with AHA at 2 referral hospitals in Seoul during the period January 2006 to December 2009 were enrolled. RESULTS: Of 1025 patients, 71 (6.9%) had AKI. The incidence of AKI was 3.1% in 2006, 6.0% in 2007, 8.9% in 2008, and 6.9% in 2009. Patients with AKI were predominantly male, heavy alcohol drinkers, and smokers, and also had a higher rate of underlying hypertension than patients without AKI. At admission, patients with AKI had significantly higher white blood cell counts, prolonged prothrombin times, and elevated liver enzymes, including total and direct bilirubin, gamma-glutamyltransferase, and C-reactive protein. Additionally, patients with AKI had a higher peak total bilirubin level and lower initial serum albumin level than patients without AKI. CONCLUSION: Although most patients with AHA complicated by AKI recover with conservative treatment, we should pay particular attention to patients who have risk factors for AKI.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91826
DOI
10.3109/00365548.2011.592145
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://informahealthcare.com/doi/abs/10.3109/00365548.2011.592145
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