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Rapid recovery of tissue hypoxia by cotransplantation of endothelial cells

Authors
 Oh, Jinsoo ; Kim, Keung Nyun ; Ha, Yoon ; Shin, Dong Ah ; Han, Seong Rok ; Yoon, Do Heum 
Citation
 Neuroreport, Vol.23(11) : 658~662, 2012 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2012
Abstract
Disruption of blood vessels caused by a spinal cord injury leads to tissue hypoxia. This hypoxic condition reduces the survival of transplanted stem cells, consequentially decreasing the effectiveness of stem cell therapy. In this study, we investigated the correlation between angiogenesis and the survival of transplanted neural stem cells in a spinal cord injury model. Hypoxia-specific luciferase-expressing neural stem cells (EpoSV-Luc NSC) were used as a tool for the detection of hypoxia caused by a spinal cord injury. In vivo, angiogenesis by cotransplantation of endothelial cells quickly recovered tissue hypoxia caused by a spinal cord injury. As a result, cotransplantation of endothelial cells improved the survival of neural stem cells transplanted into the injured spinal cord.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91545
DOI
10.1097/WNR.0b013e3283555d1b
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
Yonsei Authors
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Link
 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201208010-00005&LSLINK=80&D=ovft
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