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Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: clinical manifestation and prognostic outcome

Authors
 Jun Soo Jeong ; Hyun Ki Kim ; Cheong Soo Park ; Woong Youn Chung ; Kee-Hyun Nam ; Jong Ju Jeong ; Sang-Wook Kang ; Jae Hyun Park ; Seulkee Park ; Cho-Rok Lee 
Citation
 Journal of Korean Medical Science, Vol.27(8) : 883~889, 2012 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2012
Abstract
The study aimed to identify the clinical characteristics of coexisting chronic lymphocytic thyroiditis (CLT) in papillary thyroid carcinoma (PTC) and to evaluate the influence on prognosis. A total of 1,357 patients who underwent thyroid surgery for PTC were included. The clinicopathological characteristics were identified. Patients who underwent total thyroidectomy (n = 597) were studied to evaluate the influence of coexistent CLT on prognosis. Among the total 1,357 patients, 359 (26.5%) had coexistent CLT. In the CLT group, the prevalence of females was higher than in the control group without CLT (P < 0.001). Mean tumor size and mean age in the patients with CLT were smaller than without CLT (P = 0.040, P = 0.047, respectively). Extrathyroidal extension in the patients with CLT was significantly lower than without CLT (P = 0.016). Among the subset of 597 patients, disease-free survival rate in the patients with CLT was significantly higher than without CLT (P = 0.042). However, the multivariate analysis did not reveal a negative association between CLT coexistence and recurrence. Patients with CLT display a greater female preponderance, smaller size, younger and lower extrathyroidal extension. CLT is not a significant independent negative predictive factor for recurrence, although presence of CLT indicates a reduced risk of recurrence.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90907
DOI
10.3346/jkms.2012.27.8.883
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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