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Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer.

Authors
 S.G. Hwang ; K.M. Kim ; S.H. Noh ; W.J. Hyung ; J.Y. An ; H.I. Kim ; J.H. Cheong 
Citation
 European Journal of Surgical Oncology, Vol.38(7) : 562~567, 2012 
Journal Title
 European Journal of Surgical Oncology 
ISSN
 0748-7983 
Issue Date
2012
Abstract
BACKGROUND: Thrombocytosis has been associated with malignancies and poor prognostic implications in cancer patients. In the present study the prognostic significance of pretreatment platelet (PLT) level was assessed with regard to recurrence and survival in patients with primary gastric adenocarcinoma. METHODS: The authors reviewed the prospective data of 1593 gastric cancer patients who received curative gastrectomy with extended lymphadenectomy. The correlations of PLT level with recurrence and overall survival were evaluated by both univariate and multivariate analyses. RESULTS: Thrombocytosis (≥ 40 × 10(4)/ μL), present in 6.4% of the patients prior to curative surgery, was more frequently associated with advanced T and N classification, larger tumor size, anemia, and leukocytosis (p < 0.05). In patients with pretreatment thrombocytosis compared to those without it, five-year survival rate was worse (56.9% vs. 65.5%; p = 0.043), and recurrence rate was higher mainly due to the frequent hematogenous spread (51.0% vs. 34.5%; p < 0.001). Furthermore, risk of blood-borne metastasis was almost three-fold higher in patients with pretreatment thrombocytosis (Odds ratio 2.83 [95% CI 1.67-4.77], p < 0.001). CONCLUSIONS: Pretreatment thrombocytosis correlated significantly with poor prognosis and can be used as an independent predictor of recurrence by blood-borne metastasis in gastric cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90241
DOI
10.1016/j.ejso.2012.04.009
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0748798312002946
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