Photosensitizer and vancomycin-conjugated novel multifunctional magnetic particles as photoinactivation agents for selective killing of pathogenic bacteria.

Kyong-Hoon Choi; Hye-Jin Lee; Bong Joo Park; Kang-Kyun Wang; Eon Pil Shin; Jong-Chul Park; Young Keun Kim; Min-Kyu Oh; Yong-Rok Kim

doi:22473513

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Photosensitizer and vancomycin-conjugated novel multifunctional magnetic particles as photoinactivation agents for selective killing of pathogenic bacteria.

Authors: Kyong-Hoon Choi ; Hye-Jin Lee ; Bong Joo Park ; Kang-Kyun Wang ; Eon Pil Shin ; Jong-Chul Park ; Young Keun Kim ; Min-Kyu Oh ; Yong-Rok Kim

Citation: CHEMICAL COMMUNICATIONS, Vol.48(38) : 4591-4593, 2012

Journal Title: CHEMICAL COMMUNICATIONS

ISSN: 1359-7345

Issue Date: 2012

MeSH: Animals ; Bacteria/drug effects* ; Cell Line ; Cell Survival/drug effects ; Ferrosoferric Oxide/chemistry ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Magnetite Nanoparticles/chemistry ; Magnetite Nanoparticles/microbiology* ; Mice ; Photosensitizing Agents/chemistry* ; Photosensitizing Agents/pharmacology* ; Surface Properties ; Vancomycin/chemistry*

Keywords: Animals ; Bacteria/drug effects* ; Cell Line ; Cell Survival/drug effects ; Ferrosoferric Oxide/chemistry ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Magnetite Nanoparticles/chemistry ; Magnetite Nanoparticles/microbiology* ; Mice ; Photosensitizing Agents/chemistry* ; Photosensitizing Agents/pharmacology* ; Surface Properties ; Vancomycin/chemistry*

Abstract: Novel multifunctional magnetic particles (MMPs) conjugated with photosensitizer and vancomycin were fabricated by surface modification of Fe(3)O(4) particles. The capacities to target, capture and inactivate pathogenic bacteria and good biocompatibility suggest that the MMPs have great potentials as photodynamic inactivation agents for serious bacterial contamination.

Full Text: http://pubs.rsc.org/en/Content/ArticleLanding/2012/CC/c2cc17766h

DOI: 22473513

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

Yonsei Authors: Park, Jong Chul(박종철) https://orcid.org/0000-0003-0083-5991

URI: https://ir.ymlib.yonsei.ac.kr/handle/22282913/89939

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