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Water-stable single-walled carbon nanotubes coated by pyrenyl polyethylene glycol for fluorescence imaging and photothermal therapy

Title
 Water-stable single-walled carbon nanotubes coated by pyrenyl polyethylene glycol for fluorescence imaging and photothermal therapy 
Authors
 Kuewhan Jang ; Kilho Eom ; Taeyun Kwon ; Woo-Jae Kim ; Eunseon Kim ; Jaemoon Yang ; Seungjoo Haam ; Jae-Hee Han ; Gyudo Lee 
Issue Date
2012
Journal Title
 Biochip Journal 
ISSN
 1976-0280 
Citation
 Biochip Journal, Vol.6(4) : 396~403, 2012 
Abstract
Nanomaterials have recently received significant attention as photothermal agents and fluorescence contrast agents for molecular therapeutics due to their unique optical properties (e.g. light absorption). In particular, single-walled carbon nanotubes (SWNTs) have been recently utilized as photothermal agents (for photothermal therapy) because of the solubility of SWNTs as well as their light absorbing capability at the near-infrared region. In this work, we have developed the SWNT-based photothermal agents using pyrene-based PEGylation of SWNTs. FT-IR and/or H-NMR spectroscopies have validated the PEGylation of SWNTs, and it is shown that water-soluble SWNTs are able to generate heat under near-infrared (NIR) irradiation of 5W/cm2. Moreover, it is found that our pyrene-based PEGylated SWNTs exhibit the fluorescence characteristic under the excitation wavelength of 340 nm. Our study sheds light on the pyrenyl PEGylated SWNTs as photothermal agents and/or fluorescence contrast agents for the future applications in molecular therapeutics.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89716
DOI
10.1007/s13206-012-6412-0
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007/s13206-012-6412-0
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