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Response evaluation in patients with colorectal liver metastases: RECIST version 1.1 versus modified CT criteria

Authors
 Woo-Suk Chung ; Mi-Suk Park ; Myeong-Jin Kim ; Jin Young Choi ; Yeo-Eun Kim ; Song-Ee Baek ; Sang Joon Shin 
Citation
 American Journal of Roentgenology, Vol.199(4) : 809~815, 2012 
Journal Title
 American Journal of Roentgenology 
ISSN
 0361-803X 
Issue Date
2012
Abstract
OBJECTIVE: Our retrospective study compared Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with modified CT criteria to determine their respective utilities as a prognostic indicator. Using both sets of criteria, we compared treatment responses of patients with colorectal liver metastases treated with bevacizumab-containing chemotherapy with those of patients treated with chemotherapy alone. MATERIALS AND METHODS: Fifty-nine patients who received bevacizumab-containing chemotherapy (n=30, group 1) or chemotherapy alone (n=29, group 2) for the treatment of colorectal carcinoma underwent contrast-enhanced CT before treatment and 2 months after treatment. Two radiologists determined changes in tumor size and density between the pretreatment and 2-month follow-up CT images. RECIST 1.1 assesses responses on the basis of changes in tumor size, and the modified CT criteria assesses responses on the basis of changes in tumor density and size. Responses were correlated with time to tumor progression by log rank test. RESULTS: According to RECIST 1.1, nine of 30 patients (30%) in group 1 and 12 of 29 patients (41%) in group 2 were good responders. According to the modified CT criteria, 23 of 30 patients in group 1 (77%) and 23 of 29 patients in group 2 (79%) were good responders. As assessed by the modified CT criteria, good responders in both groups had significantly longer time to tumor progression than poor responders (p<0.05). As assessed by RECIST 1.1, good responders in group 1 had significantly longer time to tumor progression than poor responders (p=0.0154), but there was no difference in group 2. CONCLUSION: Evaluating treatment response with tumor size and density changes on CT was a better predictor of time to tumor progression than changes in tumor size alone in both groups.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89450
DOI
abs/10.2214/AJR.11.7910
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Ophthalmology
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://www.ajronline.org/doi/abs/10.2214/AJR.11.7910
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