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Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women

Authors
 Hye Yeon Kim ; SiHyun Cho ; Byung Seok Lee ; Seok Kyo Seo ; Kyung Eun Lee ; Hyo In Yang ; Young Sik Choi 
Citation
 American Journal of Reproductive Immunology, Vol.68(3) : 238~243, 2012 
Journal Title
 American Journal of Reproductive Immunology 
ISSN
 1046-7408 
Issue Date
2012
Abstract
PROBLEM: We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women. METHOD OF STUDY: This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis. RESULTS: There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06-0.30). CONCLUSIONS: We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89442
DOI
10.1111/j.1600-0897.2012.01151.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2012.01151.x/abstract
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