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Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women

Authors
 Hye Yeon Kim  ;  SiHyun Cho  ;  Young Sik Choi  ;  Hyo In Yang  ;  Kyung Eun Lee  ;  Seok Kyo Seo  ;  Byung Seok Lee 
Citation
 AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Vol.68(3) : 238-243, 2012 
Journal Title
 AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 
ISSN
 1046-7408 
Issue Date
2012
MeSH
Adolescent ; Adult ; Alleles ; Asian Continental Ancestry Group* ; Case-Control Studies ; Cyclooxygenase 2/genetics* ; Endometriosis/ethnology ; Endometriosis/genetics* ; Endometriosis/pathology ; Endometrium/metabolism* ; Endometrium/pathology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Korea/epidemiology ; Middle Aged ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide* ; Risk ; Severity of Illness Index
Keywords
Cyclooxygenase-2 gene ; endometriosis ; polymorphism
Abstract
PROBLEM: We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women. METHOD OF STUDY: This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis. RESULTS: There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06-0.30). CONCLUSIONS: We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2012.01151.x/abstract
DOI
22587873
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Yeon(김혜연)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yang, Hyo In(양효인)
Lee, Kyung Eun(이경은)
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89442
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