Osteonecrosis of the jaw related to everolimus: a case report
Dong Wook Kim ; Young-Soo Jung ; Hwi-Dong Jung ; Hyung-Sik Park
British Journal of Oral & Maxillofacial Surgery, Vol.51(8) : e302~e304, 2013
British Journal of Oral & Maxillofacial Surgery
Antiresorptive agent-related osteonecrosis of the jaw results in appreciable morbidity in affected patients. Nowadays many physicians prescribe an antiangiogenic agent for the management of malignant metastases. Everolimus is a serine-threonine kinase that acts as an inhibitor of mammalian target of rapamycin, which results in reduced growth of cells, angiogenesis, and survival of cells. We report the first case to our knowledge of osteonecrosis of the jaw that seemed to result from the additive effect of everolimus.