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A Biodegradable Polymersome Containing Bcl-xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect

Title
A Biodegradable Polymersome Containing Bcl-xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect
Authors
Eunjung Kim;Hyun-Ouk Kim;Seungjoo Haam;Yong-Min Huh;Jin-Suck Suh;Dong-Joo Kim;Byunghoon Kang;Myeong-Hoon Kim;Aastha Kukreja;Eun Bi Choi;Eunji Jang;Jihye Choi;Yonghee An
Issue Date
2013
Journal Title
Macromolecular Bioscience
ISSN
1616-5187
Citation
Macromolecular Bioscience, Vol.13(6) : 745~754, 2013
Abstract
Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.
URI
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201200448/abstract

http://ir.ymlib.yonsei.ac.kr/handle/22282913/86820
DOI
10.1002/mabi.201200448
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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