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CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Title
 CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells 
Authors
 Jungmin Park ; Minhee Ku ; Jaemoon Yang ; Yong-Min Huh ; Jin-Suck Suh ; Eun Sung Park ; Jae-Ho Cheong ; Seungjoo Haam ; Yoochan Hong ; Yeonji Park ; Eunjung Kim 
Issue Date
2013
Journal Title
 Integrative Biology 
ISSN
 1757-9694 
Citation
 Integrative Biology, Vol.5(4) : 669~672, 2013 
Abstract
We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86740
DOI
10.1039/c3ib20203h
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 5. Research Institutes > Institute for Medical Convergence
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://pubs.rsc.org/en/Content/ArticleLanding/2013/IB/c3ib20203h#!divAbstract
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