Cited 0 times in

Xanthorrhizol induces apoptotic cell death through molecular cross talks between mitochondria-dependent and death receptor-mediated signaling in human promyelocytic leukemia cells

Title
 Xanthorrhizol induces apoptotic cell death through molecular cross talks between mitochondria-dependent and death receptor-mediated signaling in human promyelocytic leukemia cells
Authors
 Hyun-Jeong Kim; Won-Yoon Chung; Kwang-Kyun Park; Jae-Kwan Hwang
Issue Date
2013
Journal Title
 Journal of Korean Association of Cancer Prevention (대한암예방학회지)
ISSN
 1229-0165
Citation
 Journal of Korean Association of Cancer Prevention (대한암예방학회지), Vol.18(1) : 41~47, 2013
Abstract
Xanthorrhizol, isolated from Curcuma xanthorrhiza, has been shown to induce cell cycle arrest and apoptotic cell death by mainly mitochondrial-dependent signaling pathway in several human cancer cells. We investigated whether xanthorrhizol could apoptosis in HL-60 human promyelocytic leukemia cells. Xanthorrhizol treatment inhibited cell viability and induced apoptotic cell death. The levels of procaspase-3, -8 and -9 were reduced and the cleavage of full length PARP was clearly observed in xanthorrhizol-treated cells. Xanthorrhizol treatment did not affect Bcl-2 protein level but increased Bax protein level, resulting in the diminished Bcl-2/Bax ratio. The levels of cleaved Bid, Fas death receptor and p53, not FasL, were also increased by xanthorrhizol treatment. In conclusion, molecular cross talks between the intrinsic and extrinsic apoptotic pathway via Bid may play an important role for induction of apoptosis in xanthorrhizol-treated HL-60 cells. Therefore, xanthorrhizol has the chemorpeventive and anti-cancer potential against human promyelocytic leukemia cells
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86722
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.kscp.or.kr/journal/view.html?book=Journal&start=0&scale=10&key=all&key_word=&Vol=018&Num=01&PG=&year1=&year2=&sort=Publisher_date+desc&aut_box=Y&sub_box=Y&sos_box=&key_box=&pub_box=Y&abs_box=&mod=vol&multi%5B%5D=1175
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse