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Changes in the blood–brain barrier status closely correlate with the rate of disease progression in patients with multiple system atrophy: A longitudinal study

Title
 Changes in the blood–brain barrier status closely correlate with the rate of disease progression in patients with multiple system atrophy: A longitudinal study 
Authors
 Ji E. Lee ; Sook K. Song ; Phil Hyu Lee ; Young H. Sohn ; Hyun-Jung Park ; Mun-Kyung Sunwoo ; Jin Yong Hong 
Issue Date
2013
Journal Title
 Parkinsonism & Related Disorders 
ISSN
 1353-8020 
Citation
 Parkinsonism & Related Disorders, Vol.19(4) : 450~452, 2013 
Abstract
BACKGROUND: The pathomechanisms responsible for disease progression in multiple system atrophy are unknown. The blood-brain barrier status may act as a modifier of disease progression in neurodegenerative diseases. METHODS: We evaluated the 12-month longitudinal change of the blood-brain barrier in 16 multiple system atrophy patients and analyzed its correlation with changes in clinical severity. RESULTS: The baseline blood-brain barrier index did not correlate significantly with change in disease severity. However, changes in the blood-brain barrier indices over 12 months had significant positive correlations with changes in total unified multiple system atrophy rating scale (r = 0.56, p = 0.024) and part II scores (r = 0.56, p = 0.025). These correlation coefficients were higher after adjusting for baseline neurological deficits. CONCLUSIONS: These data suggest that changes in the blood-brain barrier status are closely coupled with the rate of disease progression in multiple system atrophy, potentially acting as a contributor to disease progression.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86522
DOI
10.1016/j.parkreldis.2012.12.002
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Life Science
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S1353802012004798
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