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Small-world networks in individuals at ultra-high risk for psychosis and first-episode schizophrenia during a working memory task

Title
 Small-world networks in individuals at ultra-high risk for psychosis and first-episode schizophrenia during a working memory task 
Authors
 Kyungun Jhung ; Sung-Hwan Cho ; Suk Kyoon An ; Kwang-Hyun Cho ; Eun Lee ; Kyung Ran Kim ; Dongkwan Shin ; Jin Young Park ; Ji-Hyun Jang 
Issue Date
2013
Journal Title
 Neuroscience Letters 
ISSN
 0304-3940 
Citation
 Neuroscience Letters, Vol.535(null) : 35~39, 2013 
Abstract
Disturbances of functional interaction between different brain regions have been hypothesized to be the major pathophysiological mechanism underlying the cognitive deficits of schizophrenia. We investigated the small-world functional networks in individuals at ultra-high risk (UHR) for psychosis, first-episode schizophrenia (FESPR) patients, and healthy controls. All participants underwent the electroencephalogram during a control task and a working memory (WM) task. Small-world properties of the theta band were reduced in FESPR relative to controls during the WM task. Small-worldness of the UHR during the WM task exhibited intermediate value between that of controls and FESPR. These results imply that the suboptimal organization of the brain network may play a pivotal role in the schizophrenia pathophysiology.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86227
DOI
10.1016/j.neulet.2012.11.051
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Psychiatry
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0304394012015467
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