TGF-β2 및 bFGF 망막색소상피세포 증식에 미치는 영향

Abstract

This study was undertaken to document the effect of transforming growth factor-β2 ( TGF-β2(TGF-β2) and basic fibroblast growth factor (bFGF) on the proliferation of pig retinal pigment epithelial cells (RPE). Whereas bFGF increased the proliferation, TGF-β2 showed the inhibitory effect on the proliferation The inhibitory effect of TGF-β2 disappeared in RPE subcultured with 10ng/ml of bFGF. Both TGF-β2- and bFGF-specific antisense oligonucleotides blocked the autocrine effect of the growth factors. PLC-71 -specific antisense oligonucleotide inhibited the effect of TGF-β2 and bFGF. Genistein inhibited the effect of TGF-β2 and bFGF in dose-dependent man, ner. The data suggest the involvement. of in PLC-/1 and tyrosine kinase in signalling