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Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats

Title
Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats
Authors
Tie Yuan Zhang;Jeong Won Jahng;Dong Goo Kim
Issue Date
2001
Journal Title
Neuroscience Letters
ISSN
0304-3940
Citation
Neuroscience Letters, Vol.309(2) : 85~88, 2001
Abstract
Dextromethorphan (DM), an antitussive widely available in over-the-counter, has been abused mostly in teenage groups at high doses. To examine effects of DM on the reward pathway, we injected a high dose of DM (40 mg/kg; intraperitoneally) into the adolescent rat and measured tyrosine hydroxylase (TH) mRNA by in situ hybridization in the ventral tegmental area (VTA) and the substantia nigra (SN). Remarkable increases in the level of TH mRNA were observed in the VTA and SN 2 h after DM injection. Stereotyped behavior and ataxia increased, and rearing decreased by DM administration. These results suggest that DM-induced increase in TH mRNA expression in mesencephalon contribute to the reinforcing property and the behavioral effects of DM.
URI
http://www.sciencedirect.com/science/article/pii/S0304394001020298

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142821
DOI
10.1016/S0304-3940(01)02029-8
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pharmacology
Yonsei Authors
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