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Newer neuroleptic treatment for behavioural and psychological symptoms (BPSD) of dementia

Title
Newer neuroleptic treatment for behavioural and psychological symptoms (BPSD) of dementia
Authors
KAE JOON YOO;Byoung Hoon Oh;JIN SOOK CHEON;JUNG HYUN LEE
Issue Date
2001
Journal Title
Geriatrics Today: Journal of the Canadian Geriatrics Society
ISSN
1496-3892
Citation
Geriatrics Today: Journal of the Canadian Geriatrics Society, Vol.4(1) : 24~27, 2001
Abstract
BACKGROUND: Dementia is a neuropsychiatric disorder characterized by cognitive impairments and behavioural and psychiatric symptoms. Various behavioural and psy- chological symptoms of dementia (BPSD) especially increase the burden to family and society. We studied the treatment efficacy and safety of risperidone and olanzapine on elderly dementia patients. METHODS: The study population consisted of 42 elderly patients who had BPSD with dementia, treated with risperi- done or olanzapine. Clinical safety and efficacy was evalu- ated by Clinical Global Impression (CGI) and side-effects checklist. Mean age was 68.2 ± 5.9 with 16 (38.1%) male and 26 (61.9%) female subjects. The types of dementia among the 42 demented patients were as follows: Alzheimer's dis- ease 25 (59.5%), vascular dementia 10 (23.8%), and other dementia 7 (16.7%). RESULTS: Mean Geriatric Dementia Scale scores was 5.5 ± 1.0. The efficacy of risperidone vs olanzapine was "markedly improved" 12.9% vs 34.0%, "moderately improved" 45.2% vs 29.9%, and "mildly improved" 32.2% vs 36.1% on CGI.The incidence of adverse reactions was 25.8% vs 36.4% respectively. CONCLUSIONS: Risperidone and olanzapine were found to be highly useful and well-tolerated antipsychotic drugs for behavioural and psychological symptoms of dementia between 1-2 mg vs 5-7.5 mg daily dosage respectively. However, proper evaluation of behave-ADAS (Alzheimer's Disease Assessment Scale), IADL (Instrumental Activity of Daily Living) and a larger number of elderly patients must be analyzed.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142578
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Psychiatry
Yonsei Authors
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