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Newer neuroleptic treatment for behavioural and psychological symptoms (BPSD) of dementia
DC Field | Value | Language |
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dc.contributor.author | 오병훈 | - |
dc.date.accessioned | 2016-02-19T11:10:53Z | - |
dc.date.available | 2016-02-19T11:10:53Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1496-3892 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142578 | - |
dc.description.abstract | BACKGROUND: Dementia is a neuropsychiatric disorder characterized by cognitive impairments and behavioural and psychiatric symptoms. Various behavioural and psy- chological symptoms of dementia (BPSD) especially increase the burden to family and society. We studied the treatment efficacy and safety of risperidone and olanzapine on elderly dementia patients. METHODS: The study population consisted of 42 elderly patients who had BPSD with dementia, treated with risperi- done or olanzapine. Clinical safety and efficacy was evalu- ated by Clinical Global Impression (CGI) and side-effects checklist. Mean age was 68.2 ± 5.9 with 16 (38.1%) male and 26 (61.9%) female subjects. The types of dementia among the 42 demented patients were as follows: Alzheimer's dis- ease 25 (59.5%), vascular dementia 10 (23.8%), and other dementia 7 (16.7%). RESULTS: Mean Geriatric Dementia Scale scores was 5.5 ± 1.0. The efficacy of risperidone vs olanzapine was "markedly improved" 12.9% vs 34.0%, "moderately improved" 45.2% vs 29.9%, and "mildly improved" 32.2% vs 36.1% on CGI.The incidence of adverse reactions was 25.8% vs 36.4% respectively. CONCLUSIONS: Risperidone and olanzapine were found to be highly useful and well-tolerated antipsychotic drugs for behavioural and psychological symptoms of dementia between 1-2 mg vs 5-7.5 mg daily dosage respectively. However, proper evaluation of behave-ADAS (Alzheimer's Disease Assessment Scale), IADL (Instrumental Activity of Daily Living) and a larger number of elderly patients must be analyzed. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 24~27 | - |
dc.relation.isPartOf | Geriatrics Today: Journal of the Canadian Geriatrics Society | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Newer neuroleptic treatment for behavioural and psychological symptoms (BPSD) of dementia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Byoung Hoon Oh | - |
dc.contributor.googleauthor | JUNG HYUN LEE | - |
dc.contributor.googleauthor | JIN SOOK CHEON | - |
dc.contributor.googleauthor | KAE JOON YOO | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02368 | - |
dc.relation.journalcode | J00944 | - |
dc.contributor.alternativeName | Oh, Byong Hoon | - |
dc.contributor.affiliatedAuthor | Oh, Byong Hoon | - |
dc.rights.accessRights | not available | - |
dc.citation.volume | 4 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 24 | - |
dc.citation.endPage | 27 | - |
dc.identifier.bibliographicCitation | Geriatrics Today: Journal of the Canadian Geriatrics Society, Vol.4(1) : 24-27, 2001 | - |
dc.identifier.rimsid | 31108 | - |
dc.type.rims | ART | - |
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