Insulin Sensitivity is Associated with the Presence and Extent of Coronary Artery Disease
권기환 ; 최동훈 ; 민필기 ; 오성진 ; 변영섭 ; 고영국 ; 구본권
Korean Circulation Journal (순환기), Vol.32(7) : 566~572, 2002
Korean Circulation Journal (순환기)
Background and Objectives : Insulin resistance has been suggested to be an important risk factor in the development of arteriosclerosis. The correlation between insulin sensitivity and the degree of coronary atherosclerosis in patients with angina pectoris was investigated. Subjects and Methods : The study population consisted of 74 subjects with angina (54 men, 20 women), aged from 31 to 73 years. Coronary angiograms were evaluated by 3 semiquantitative scoring systems (vessel score, stenosis score and extent score) to estimate the extent of focal and diffuse coronary artery disease (CAD). Insulin sensitive insulin tolerance test. Results : There were significant correlations between , (PTT) was determined co an IC,TT and all 3 sres.
Multivariate analysis revealed significant and independent correlations between all 3 coronary scores and Km, even in patients without diabetes mellitus. Both HDL cholesterol level and KnT were significantly lower in patients with CAD than in those without. Conclusion : Decreased insulin sensitivity was significantly associated with the presence and extent of CAD. These results suggest the potential benefits of insulin-sensitizing treatment strategies for patients with decreased insulin sensitivity.