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Generation of Demyelination through Use of M. leprae-specific phenolic glycolipid-1 (PGL-1)

Title
Generation of Demyelination through Use of M. leprae-specific phenolic glycolipid-1 (PGL-1)
Authors
Kim, Ji-Young;Choi, Chang-Shik;Hong, Seong-Karp
Issue Date
2015
Journal Title
Rapid Communication in Photoscience
ISSN
2288-4564
Citation
Rapid Communication in Photoscience , Vol.4(2) : 48~49, 2015
Abstract
For myelination, Schwann cells and neuron cells from dorsal root ganglion (DRG) of rat embryos (E16) were cultured in vitro system. The purified DRG cells with anti-mitotic agents and purified Schwann cells were cocultured and then accomplished myelination processing. Treatment of M. leprae-specific phenolic glycolipid-1 (PGL-1) into this coculture system was performed and then accomplished demyelination. Therefore, we identified demyelination processing using antibody of myelin basic protein (MBP).
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/141672
DOI
10.5857/RCP.2015.4.2.48
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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