Generation of Demyelination through Use of M. leprae-specific phenolic glycolipid-1 (PGL-1)
Kim, Ji-Young ; Choi, Chang-Shik ; Hong, Seong-Karp
Rapid Communication in Photoscience , Vol.4(2) : 48~49, 2015
Rapid Communication in Photoscience
For myelination, Schwann cells and neuron cells from dorsal root ganglion (DRG) of rat embryos (E16) were cultured in vitro system. The purified DRG cells with anti-mitotic agents and purified Schwann cells were cocultured and then accomplished myelination processing. Treatment of M. leprae-specific phenolic glycolipid-1 (PGL-1) into this coculture system was performed and then accomplished demyelination. Therefore, we identified demyelination processing using antibody of myelin basic protein (MBP).