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Generation of Demyelination through Use of M. leprae-specific phenolic glycolipid-1 (PGL-1)

Authors
 Kim, Ji-Young ; Choi, Chang-Shik ; Hong, Seong-Karp 
Citation
 Rapid Communication in Photoscience , Vol.4(2) : 48~49, 2015 
Journal Title
 Rapid Communication in Photoscience 
ISSN
 2288-4564 
Issue Date
2015
Abstract
For myelination, Schwann cells and neuron cells from dorsal root ganglion (DRG) of rat embryos (E16) were cultured in vitro system. The purified DRG cells with anti-mitotic agents and purified Schwann cells were cocultured and then accomplished myelination processing. Treatment of M. leprae-specific phenolic glycolipid-1 (PGL-1) into this coculture system was performed and then accomplished demyelination. Therefore, we identified demyelination processing using antibody of myelin basic protein (MBP).
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141672
DOI
10.5857/RCP.2015.4.2.48
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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