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A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis.

Title
A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis.
Authors
Jong-Min Lee;Kyoung-Won Cho;Han-Sung Jung;Cheryll Tickle;Kye-Seong Kim;Qinghuang Tang;Eun-Jung Kim
Issue Date
2015
Journal Title
Oncotarget
ISSN
1949-2553
Citation
Oncotarget, Vol.6(26) : 22048~22059, 2015
Abstract
MicroRNAs are differentially expressed in breast cancer cells and have been implicated in cancer formation, tumour invasion and metastasis. We investigated the miRNA expression profiles in the developing mammary gland. MiR-137 was expressed prominently in the developing mammary gland. When the miR-137 was over-expressed in the embryo, the mammary epithelium became thickened. Moreover, genes associated with mammary gland formation such as Tbx3 and Lef1 were not expressed. This suggests that miR-137 induces gland formation and invasion. When miR-137 was over-expressed in MDA-MB-231 cells, their ability to form tumours in adult mice was significantly reduced. These data support miR-137 decides epithelial cell behavior in the human breast cancer. It also suggests that miR-137 is a potential therapeutic target for amelioration of breast cancer progression.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/141123
DOI
10.18632/oncotarget.4218
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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