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Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success

Authors
 Eue Keun Choi ; Jae Hyung Park ; Hui Nam Pak ; Patrick T. Ellinor ; Steven A. Lubitz ; Moon Hyoung Lee ; Young Guk Ko ; Boyoung Joung ; Jae Sun Uhm ; Min Ki Hwang ; Chung Mo Nam ; Ji Young Lee 
Citation
 Journal of the American Heart Association, Vol.4(8) : 1~9, 2015 
Journal Title
 Journal of the American Heart Association 
ISSN
 2047-9980 
Issue Date
2015
Abstract
BACKGROUND: Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF. METHODS AND RESULTS: We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 67.9% paroxysmal AF) and 1068 age- and sex-matched controls. The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). Among those patients who underwent catheter ablation for AF, none of the top AF-associated SNPs were associated with long-term clinical recurrence of AF after catheter ablation. CONCLUSIONS: SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF-susceptibility SNPs predicted clinical recurrence after catheter ablation.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140945
DOI
10.1161/JAHA.115.002046
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 5. Research Institutes > Yonsei Cardiovascular Research Institute
1. 연구논문 > 1. College of Medicine > Dept. of Preventive Medicine
Yonsei Authors
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