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Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success

Authors
 Eue Keun Choi  ;  Jae Hyung Park  ;  Ji Young Lee  ;  Chung Mo Nam  ;  Min Ki Hwang  ;  Jae Sun Uhm  ;  Boyoung Joung  ;  Young Guk Ko  ;  Moon Hyoung Lee  ;  Steven A. Lubitz  ;  Patrick T. Ellinor  ;  Hui Nam Pak 
Citation
 JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.4(8) : 1-9, 2015 
Journal Title
 JOURNAL OF THE AMERICAN HEART ASSOCIATION 
Issue Date
2015
MeSH
Aged ; Asian Continental Ancestry Group/genetics ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/ethnology ; Atrial Fibrillation/genetics ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery* ; Case-Control Studies ; Catheter Ablation*/adverse effects ; Chi-Square Distribution ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Heart Conduction System/physiopathology ; Heart Conduction System/surgery* ; Homeodomain Proteins/genetics* ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Phenotype ; Polymorphism, Single Nucleotide* ; Proportional Hazards Models ; Recurrence ; Republic of Korea ; Risk Assessment ; Risk Factors ; Small-Conductance Calcium-Activated Potassium Channels/genetics ; Time Factors ; Transcription Factors/genetics* ; Treatment Outcome
Keywords
atrial fibrillation ; catheter ablation ; genetic polymorphism ; phenotype ; recurrence
Abstract
BACKGROUND: Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF. METHODS AND RESULTS: We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 67.9% paroxysmal AF) and 1068 age- and sex-matched controls. The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). Among those patients who underwent catheter ablation for AF, none of the top AF-associated SNPs were associated with long-term clinical recurrence of AF after catheter ablation. CONCLUSIONS: SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF-susceptibility SNPs predicted clinical recurrence after catheter ablation.
Files in This Item:
T201503085.pdf Download
DOI
10.1161/JAHA.115.002046
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Uhm, Jae Sun(엄재선) ORCID logo https://orcid.org/0000-0002-1611-8172
Lee, Moon Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Lee, Ji Young(이지영) ORCID logo https://orcid.org/0000-0002-7784-1401
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
Hwang, Min Ki(황민기)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140945
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