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Muscle weakness after repeated injection of botulinum toxin type a evaluated according to bite force measurement of human masseter muscle

Issue Date
2011
Description
Dept. of Dental Science/박사
Abstract
Botulinum toxin type A (BTX-A) has been applied successfully to treat masseteric hypertrophy, but it can cause muscle weakness. To measure the change in maximum bite force (MBF) after BTX-A injection into the human masseter muscle and to evaluate the influence of a booster (repeated) injection, thirty volunteers completed 18-week follow-up, and MBF was measured. At 18 weeks after the first injection, a booster injection was given to 14 patients, and they were followed up until 18 weeks from the booster injection.Mean MBF was approximately 20% lower at 2 weeks than before the injection, and it recovered gradually after 4 weeks to return to the preinjection level at 12 weeks. MBF differed significantly between before the injection and at 2, 4, and 8 weeks after the injection (p<0.05).In the booster injection group (n = 14), MBF was markedly lower at 6 weeks (p<0.05), and it recovered gradually in 12 weeks. In conclusion, MBF was significantly lower after booster injection of BTX-A into the human masseter muscle, but it gradually recovered in a predictable pattern, and the degree of discomfort experienced by the subjects had little effect on normal mastication.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/133924
Appears in Collections:
2. 학위논문 > 2. College of Dentistry (치과대학) > 박사
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