(A) study of the isolation of tubercle bacilli from the patient's urine with genitourinary tuberculosis by the inoculation into the Korean chipmunks(Tamias sibiricus asiaticus, gmelin
Authors
최형기
Issue Date
1973
Description
의학과/석사
Abstract
[한글]
A STUDY OF THE ISOLATION OF TUBERCLE BACILLI FROM THE PATIENT'S URINE WITH
GENITOURINARY TUBERCULOSIS BY THE INOCULATION INTO THE KOREAN CHIPMUNKS(TAMIAS,
SIBIRICUS ASIATIUS, GMELIN)
HYUNG KI CHOI
Department of Medical Science The Graduate School Yonsei University
(Directed by professor Chong Soon Wang)
The detection of the tubercle bacilli is absolutely necessary to make definite
diagnosis of patients with genitourinary tuberculosis. Recently it has been
reported that the detection rate of tubercle bacilli from the patient's urine is
decreasing because of abuse of the anti-tuberculous drugs and the resistance
developed in the experimental animals such as mouse and guinea pig (Marks, 1972).
Therefore the necessity of the development of better diagnostic method has been
mandatory. Recently it was reported that the korean chipmunks(Tamias sibiricus
asiaticus, Gmelin) are highly susceptible to tubercle bacilli (Chang et al., 1971).
The specific objection of this study is to persue the possibility of using the
chipmunks for the early diagnosis of genitourinary tuberculosis.
Twenty-four hour urines of 34 patients with suspected genitourinary tuberculosis
were tested for tubercle bacilli with smear, culture, and inoculation into
chipmunks and mice intraperitoneally.
The results are briefly summarized as follows:
1. 18 cases out of 34 patients with suspected genitourinary tuberculosis were
confirmed to be positive by any means of stained smear, culture and animal
inoculation. Of 18 proved genitourinary tuberculosis, 12 cases were confirmed by
smear, culture and mouse inoculation.
2. In the group of chipmunks inoculation, 8cases were found to be positive on the
10th day and 14 cases on the 20th day.
3. These findings suggest that the period required for the detection of tubercle
bacilli was shorter and the positive rate was higher than that of other animals and
other methods. For the clinical applications of the Korean chipmunks as a
diagnostic tools, further effort is considered to be necessary.
[영문]
The detection of the tubercle bacilli is absolutely necessary to make definite diagnosis of patients with genitourinary tuberculosis. Recently it has been reported that the detection rate of tubercle bacilli from the patient's urine is decreasing because of abuse of the anti-tuberculous drugs and the resistance
developed in the experimental animals such as mouse and guinea pig (Marks, 1972).
Therefore the necessity of the development of better diagnostic method has been mandatory. Recently it was reported that the korean chipmunks(Tamias sibiricus asiaticus, Gmelin) are highly susceptible to tubercle bacilli (Chang et al., 1971).
The specific objection of this study is to persue the possibility of using the chipmunks for the early diagnosis of genitourinary tuberculosis.
Twenty-four hour urines of 34 patients with suspected genitourinary tuberculosis were tested for tubercle bacilli with smear, culture, and inoculation into chipmunks and mice intraperitoneally.
The results are briefly summarized as follows:
1. 18 cases out of 34 patients with suspected genitourinary tuberculosis were confirmed to be positive by any means of stained smear, culture and animal inoculation. Of 18 proved genitourinary tuberculosis, 12 cases were confirmed by smear, culture and mouse inoculation.
2. In the group of chipmunks inoculation, 8cases were found to be positive on the 10th day and 14 cases on the 20th day.
3. These findings suggest that the period required for the detection of tubercle bacilli was shorter and the positive rate was higher than that of other animals and other methods. For the clinical applications of the Korean chipmunks as a diagnostic tools, further effort is considered to be necessary.