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원발성 간암에서의 Alpha₁- Fetoprotein 양성군과 음성군간의 임상적 및 병리조직학적 소견의 차이에 대한 연구

Other Titles
 (The) differences in clinical and pathological findings between Alpha₁-Fetoprotein positive and negative groups of the hepatoma 
Issue Date
1974
Description
의학과/석사
Abstract
[한글] The Differences in Clinical and Pathological Findings between Alpha-l-Fetoprotein Positive and Negative Groups of the Hepatoma Seung Yun Cho Department of Medical Science The Graduate School Yonsei University (Directed by Prof. Heung Jai Choi) Although alph-l-fetoprotein(AFP), a normal alpha-l-globulin during fetal life, has been proven to be of value in the diagnosis of hepatoma, little is known about the differences in clinical and pathological findings between AFP positive and negative groups of the hepatoma. Sera from 191 patients with the diagnosis of hepatoma were tested for the presence of AFP using an Micro-Ouchterlony double immunodiffusion technique. We correlated the presence of AFP with the clinical and pathological features. The following results were obtained: 1. Serum AFP was positive in 117 out of 191 patients with hepatome (61.6%). Among the 191 patients with hepatoma, the diagnosis was confirmed pathologically in 76 and was made clinically in 115. In 45 out of 76 pathologically confirmed cases (59.2%), and in 72 out of 115 clinically diagnosed cases (62.6%), the serum AFP was positive. 2. The male to female ratio of patients with hepatoma was 5.2:1. A greater percentage of female patients with hepatoma than male patients had AFP positive serum(67.7% versus 60.0%), but this difference was statistically not significant(P>0.10). 3. The majority of the patients with hepatoma was in 5th and 6 th decades. The fact that serum AFP appeared more frequently in younger patients and less frequently in older patients has been observed. 4. the occurrence of AFP was highly frequent in patients with metastatic hepatoma(91.7%). 5. Those patients with AFP positive hepatoma had a higher serum total cholesterol than patients with AFP negative hepatoma(246±18 mg% versus 183±11 mg%, P<0.01). However, there was no close relationship between the presence of AFP in the serum and any other clinical feature or biochemaical tests, such as the duration of symptoms, liver size, serum bilirubin, and alkaline phosphatase levels. 6. Patients with poorly differentiated hepatoma and with hepatoma with basohpilic cytoplasm tended to be AFP positive. 7. There was a higher AFP occurrence in patients with hepatoma associated with cirrhosis than in those without cirrhosis(64.3% versus 47.3%), but this difference was statistically not significant(P>0.10).
[영문] Although alph-l-fetoprotein(AFP), a normal alpha-l-globulin during fetal life, has been proven to be of value in the diagnosis of hepatoma, little is known about the differences in clinical and pathological findings between AFP positive and negative groups of the hepatoma. Sera from 191 patients with the diagnosis of hepatoma were tested for the presence of AFP using an Micro-Ouchterlony double immunodiffusion technique. We correlated the presence of AFP with the clinical and pathological features. The following results were obtained: 1. Serum AFP was positive in 117 out of 191 patients with hepatome (61.6%). Among the 191 patients with hepatoma, the diagnosis was confirmed pathologically in 76 and was made clinically in 115. In 45 out of 76 pathologically confirmed cases (59.2%), and in 72 out of 115 clinically diagnosed cases (62.6%), the serum AFP was positive. 2. The male to female ratio of patients with hepatoma was 5.2:1. A greater percentage of female patients with hepatoma than male patients had AFP positive serum(67.7% versus 60.0%), but this difference was statistically not significant(P>0.10). 3. The majority of the patients with hepatoma was in 5th and 6 th decades. The fact that serum AFP appeared more frequently in younger patients and less frequently in older patients has been observed. 4. the occurrence of AFP was highly frequent in patients with metastatic hepatoma(91.7%). 5. Those patients with AFP positive hepatoma had a higher serum total cholesterol than patients with AFP negative hepatoma(246±18 mg% versus 183±11 mg%, P<0.01). However, there was no close relationship between the presence of AFP in the serum and any other clinical feature or biochemaical tests, such as the duration of symptoms, liver size, serum bilirubin, and alkaline phosphatase levels. 6. Patients with poorly differentiated hepatoma and with hepatoma with basohpilic cytoplasm tended to be AFP positive. 7. There was a higher AFP occurrence in patients with hepatoma associated with cirrhosis than in those without cirrhosis(64.3% versus 47.3%), but this difference was statistically not significant(P>0.10).
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/117043
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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