YUHSpace

BROWSE

YUHSpace

Browsing by Yonsei Author : Bok, Jin Woong

eperson profile image
Name :
Bok, Jin Woong [복진웅]
orcid http://orcid.org/0000-0003-1958-1872
Department :
College of Medicine (의과대학) - Dept. of Anatomy (해부학교실)
Scopus ID :
Scopus (25222398800)
Medical Student Research Advisor

교수 기본정보

세부 전공
인체발생학
이메일
bokj@yuhs.ac

실험실 기본정보

이름
Auditory Neuroscience Laboratory
위치
ABMRC 209
구분
Wet Lab (80%), Dry Lab (20%)
홈페이지
홈페이지 바로가기

연구소개

연구 분야
연구 내용
- 내이 발생학 (Cochlear Development) - 단순한 형태의 Otocyst가 복잡한 나선형 구조인 달팽이관으로 성숙하는 과정은 정교한 유전자 조절을 필요로 합니다. 본 연구실은 NGS 및 RNA 분석 기술을 활용하여 달팽이관의 발달 네트워크를 해독합니다.
- 주파수 감지 특성 및 정렬 (Tonotopic Organization) - 달팽이관은 기저부(Base)에서 고주파를, 첨부(Apex)에서 저주파를 감지하는 정교한 공간적-주파수 맵을 가집니다. 본 연구실은 달팽이관 형성 과정에서 이러한 주파수 정렬이 확립되는 분자적 기전을 추적합니다.
- 부동모 구조 및 아키텍처 (Stereociliary Architecture) - 청각 유모세포 상단의 부동모(Stereocilia)는 소리 진동을 전기 신호로 바꾸는 핵심 구조물입니다. 우리는 부동모 사이의 결합 구조와 정밀한 계단식 배열이 형성되는 원리를 연구하여, 구조적 결함에 의한 난청 치료 표적을 발굴합니다.
- 청각 장애 및 치료 (Hearing Loss & Therapeutics) - 청각은 단순한 감각을 넘어 소통과 정서적 안녕을 지탱하는 필수 기능입니다. 본 연구실은 노화, 소음, 유전 및 이독성 약물에 의한 난청의 근본적인 병리 기전을 연구하며, 이를 제어하기 위한 혁신적인 치료 전략을 수립합니다.

학생 참여 정보

학생들이 참여하면 좋을 연구
  • 사전 상담을 통해 현재 본 연구실에서 진행 중인 연구 주제 중 학생의 관심 분야에 부합하는 주제를 선정한 뒤, 지도교수의 지도 아래 해당 연구를 수행 중인 대학원생, 박사후연구원, 또는 연구교수와 긴밀히 협력하여 실질적인 연구를 진행하게 됨.
참여 전 준비사항
  • 실험동물부 이용자 교육 이수

Keyword Cloud

Researcher Network

Showing results 51 to 82 of 82

This table browses all dspace content
Issue DateTitleJournal Title
2014Pax3 function is required specifically for inner ear structures with melanogenic fatesBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2013Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2013Conditional Deletion of Pten Leads to Defects in Nerve Innervation and Neuronal Survival in Inner Ear Development PLOS ONE
2013Destabilization and Mislocalization of POU3F4 by C-Terminal Frameshift Truncation and Extension MutationHUMAN MUTATION
2013Genetic analysis of the CHD7 gene in Korean patients with CHARGE syndromeGENE
2013A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development DEVELOPMENTAL DYNAMICS
2012Developmental Gene Expression Profiling along the Tonotopic Axis of the Mouse Cochlea PLOS ONE
2012Nonsyndromic X-linked hearing loss.FRONTIERS IN BIOSCIENCE
2011Albumin-like protein is the major protein constituent of luminal fluid in the human endolymphatic sac. PLOS ONE
2011CHD7 mutational analysis and clinical considerations for auditory rehabilitation in deaf patients with CHARGE syndrome. PLOS ONE
2011Grp78 is a Novel Downstream Target Gene of Hoxc8 Homeoprotein Journal of Experimental & Biomedcal Science (대한의생명과학회지)
2011Functional evaluation of GJB2 variants in nonsyndromic hearing loss MOLECULAR MEDICINE
2011Identification of genes concordantly expressed with Atoh1 during inner ear development Anatomy and Cell Biology
2011Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2011Pou3f4 deficiency causes defects in otic fibrocytes and stria vascularis by different mechanismsBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2010Clinical evaluation of DFN3 patients with deletions in the POU3F4 locus and detection of carrier female using MLPA.CLINICAL GENETICS
2010Retinoic Acid Induces Abnormal Palate During Embryogenesis in Rat Journal of Experimental & Biomedcal Science (대한의생명과학회지)
2010Building the mammalian cochlea — an overviewGENES & GENOMICS
2010Proliferating cell nuclear antigen (Pcna) as a direct downstream target gene of Hoxc8BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2010Hoxc8 represses BMP-induced expression of Smad6MOLECULES AND CELLS
2010Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesisDEVELOPMENTAL BIOLOGY
2009Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein. PHYSIOLOGICAL GENOMICS
2009Different functional consequences of two missense mutations in the GJB2 gene associated with non-syndromic hearing loss.HUMAN MUTATION
2008The third helix of the murine Hoxc8 homeodomain facilitates protein transduction in mammalian cellsBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2007CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neuronsMOLECULAR AND CELLULAR NEUROSCIENCE
2007Patterning and morphogenesis of the vertebrate inner ear INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
2007Role of hindbrain in inner ear morphogenesis: Analysis of Noggin knockout miceDEVELOPMENTAL BIOLOGY
2007Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear DEVELOPMENT
2005Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear DEVELOPMENT
2003Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neuronsJOURNAL OF NEUROSCIENCE RESEARCH
2003An extranuclear locus of cAMP-dependent protein kinase action is necessary and sufficient for promotion of spiral ganglion neuronal survival by cAMP JOURNAL OF NEUROSCIENCE
2001Multiple Distinct Signal Pathways, Including an Autocrine Neurotrophic Mechanism, Contribute to the Survival-Promoting Effect of Depolarization on Spiral Ganglion Neurons In Vitro JOURNAL OF NEUROSCIENCE
12
  • License
    sherpa_romeo
    sherpa_juliet

OAK

DSpace Software Copyright © 2002-2017 Duraspace Yonsei University Medical Library All right Reserves. / TEL:02-2228-2915 /
YUHSpace는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.

Browse

Links