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A Competing Risk Analysis of Cancer-Specific Mortality of Initial Treatment with Radical Prostatectomy versus Radiation Therapy in Clinically Localized High-Risk Prostate Cancer

DC FieldValueLanguage
dc.contributor.author강호원-
dc.contributor.author권종규-
dc.contributor.author금기창-
dc.contributor.author금웅섭-
dc.contributor.author리칠다-
dc.contributor.author이주용-
dc.contributor.author제성욱-
dc.contributor.author조강수-
dc.contributor.author최영득-
dc.contributor.author함원식-
dc.date.accessioned2015-01-06T17:26:51Z-
dc.date.available2015-01-06T17:26:51Z-
dc.date.issued2014-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99996-
dc.description.abstractBACKGROUND: There is no consensus on the optimal treatment for localized high-risk prostate cancer (PC), and much debate exists regarding the ideal treatment approach. For these reasons, we evaluated the competing risks of PC-specific mortality after initial therapy with radical prostatectomy (RP) versus radiotherapy (RT) in men with clinically localized high-risk PC. METHODS: We reviewed patients treated with RP and RT combined with androgen-deprivation therapy between 1990 and 2009. High-risk PC is defined as clinical stage ≥T3a, serum prostate-specific antigen (PSA) >20 ng/mL, or a biopsy Gleason sum of 8-10 according to National Comprehensive Cancer Network guidelines. Competing risk analysis was conducted to assess the association of RP (n = 251) or RT (n = 125) with cancer-specific mortality (CSM). Thereafter, secondary analysis with propensity score matching was conducted to further elucidate patient characteristics, with optimal matching of 0.25 times the standard deviation of propensity scores. RESULTS: With an overall median follow-up of 76 months, 35 (9.3 %) men with high-risk PC died due to PC (23 in the RT group and 12 in the RP group). The 5-year estimates of cancer-specific survival rate for men treated with RP and RT were 96.5 % (95 % confidence interval [CI] 94.2-98.9) and 88.3 % (95 % CI 82.8-94.3), respectively. Cumulative incidence estimates for CSM were statistically increased amongst men treated with RT (p = 0.002). Propensity score matching extracted 168 men with high-risk PC from the total patient cohort. Cumulative incidence estimates for CSM were statistically different amongst men treated with RT (p < 0.001).-
dc.description.statementOfResponsibilityopen-
dc.format.extent4026~4033-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHPrognosis-
dc.subject.MESHPropensity Score-
dc.subject.MESHProstatectomy*-
dc.subject.MESHProstatic Neoplasms/mortality*-
dc.subject.MESHProstatic Neoplasms/radiotherapy-
dc.subject.MESHProstatic Neoplasms/surgery-
dc.subject.MESHRadiotherapy*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Rate-
dc.titleA Competing Risk Analysis of Cancer-Specific Mortality of Initial Treatment with Radical Prostatectomy versus Radiation Therapy in Clinically Localized High-Risk Prostate Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorJoo Yong Lee-
dc.contributor.googleauthorKang Su Cho-
dc.contributor.googleauthorJong Kyou Kwon-
dc.contributor.googleauthorSeong Uk Jeh-
dc.contributor.googleauthorHo Won Kang-
dc.contributor.googleauthorRichilda Red Diaz-
dc.contributor.googleauthorWon Sik Ham-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorYoung Deuk Choi-
dc.identifier.doi10.1245/s10434-014-3780-9-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00097-
dc.contributor.localIdA00250-
dc.contributor.localIdA00272-
dc.contributor.localIdA00273-
dc.contributor.localIdA01339-
dc.contributor.localIdA03161-
dc.contributor.localIdA03796-
dc.contributor.localIdA03801-
dc.contributor.localIdA04111-
dc.contributor.localIdA04337-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid24841351-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-014-3780-9-
dc.subject.keywordProstate Cancer-
dc.subject.keywordPropensity Score-
dc.subject.keywordRadical Prostatectomy-
dc.subject.keywordNational Comprehensive Cancer Network-
dc.subject.keywordNational Comprehensive Cancer Network-
dc.contributor.alternativeNameKang, Ho Won-
dc.contributor.alternativeNameKwon, Jong Kyou-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameDiaz, Richilda Red-
dc.contributor.alternativeNameLee, Joo Yong-
dc.contributor.alternativeNameJeh, Seong Uk-
dc.contributor.alternativeNameCho, Kang Su-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameHam, Won Sik-
dc.contributor.affiliatedAuthorKang, Ho Won-
dc.contributor.affiliatedAuthorKwon, Jong Kyou-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorDiaz, Richilda Red-
dc.contributor.affiliatedAuthorLee, Joo Yong-
dc.contributor.affiliatedAuthorJeh, Seong Uk-
dc.contributor.affiliatedAuthorCho, Kang Su-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorHam, Won Sik-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number12-
dc.citation.startPage4026-
dc.citation.endPage4033-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.21(12) : 4026-4033, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers

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