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Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum

DC FieldValueLanguage
dc.contributor.author남기택-
dc.date.accessioned2015-01-06T17:26:31Z-
dc.date.available2015-01-06T17:26:31Z-
dc.date.issued2014-
dc.identifier.issn0017-5749-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99986-
dc.description.abstractOBJECTIVE: The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. We examined in detail the distribution of the full range of cell lineages within the human stomach. DESIGN: We determined the distribution of gastric gland cell lineages with specific immunocytochemical markers in entire stomach specimens from three non-obese organ donors. RESULTS: The anatomical body and antrum of the human stomach were defined by the presence of ghrelin and gastrin cells, respectively. Concentrations of somatostatin cells were observed in the proximal stomach. Parietal cells were seen in all glands of the body of the stomach as well as in over 50% of antral glands. MIST1 expressing chief cells were predominantly observed in the body although individual glands of the antrum also showed MIST1 expressing chief cells. While classically described antral glands were observed with gastrin cells and deep antral mucous cells without any parietal cells, we also observed a substantial population of mixed type glands containing both parietal cells and G cells throughout the antrum. CONCLUSIONS: Enteroendocrine cells show distinct patterns of localisation in the human stomach. The existence of antral glands with mixed cell lineages indicates that human antral glands may be functionally chimeric with glands assembled from multiple distinct stem cell populations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1711~1720-
dc.relation.isPartOfGUT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell Lineage*-
dc.subject.MESHEnteroendocrine Cells/metabolism*-
dc.subject.MESHGastric Mucosa/cytology-
dc.subject.MESHGastric Mucosa/metabolism-
dc.subject.MESHGastrins/metabolism-
dc.subject.MESHGhrelin/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHParietal Cells, Gastric/cytology-
dc.subject.MESHParietal Cells, Gastric/metabolism-
dc.subject.MESHPyloric Antrum/cytology-
dc.subject.MESHPyloric Antrum/metabolism-
dc.subject.MESHSomatostatin/metabolism-
dc.subject.MESHStomach/cytology*-
dc.subject.MESHStomach/metabolism*-
dc.titleCell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorEunyoung Choi-
dc.contributor.googleauthorJoseph T Roland-
dc.contributor.googleauthorBrittney J Barlow-
dc.contributor.googleauthorRyan O'Neal-
dc.contributor.googleauthorAmy E Rich-
dc.contributor.googleauthorKi Taek Nam-
dc.contributor.googleauthorChanjuan Shi-
dc.contributor.googleauthorJames R Goldenring-
dc.identifier.doi10.1136/gutjnl-2013-305964-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01243-
dc.relation.journalcodeJ00953-
dc.identifier.eissn1468-3288-
dc.identifier.pmid24488499-
dc.identifier.urlhttp://gut.bmj.com/content/63/11/1711.long-
dc.subject.keywordGastric Epithelial Cell FUnction-
dc.subject.keywordGastric Function-
dc.subject.keywordGastric Parietal Cell-
dc.subject.keywordGastric Physiology-
dc.subject.keywordGastrin-
dc.contributor.alternativeNameNam, Ki Taek-
dc.contributor.affiliatedAuthorNam, Ki Taek-
dc.rights.accessRightsfree-
dc.citation.volume63-
dc.citation.number11-
dc.citation.startPage1711-
dc.citation.endPage1720-
dc.identifier.bibliographicCitationGUT, Vol.63(11) : 1711-1720, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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