Cited 25 times in
Co-transplantation of bone marrow-derived mesenchymal stem cells and nanospheres containing FGF-2 improve cell survival and neurological function in the injured rat spinal cord
DC Field | Value | Language |
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dc.contributor.author | 김긍년 | - |
dc.contributor.author | 신동아 | - |
dc.contributor.author | 윤도흠 | - |
dc.contributor.author | 하윤 | - |
dc.date.accessioned | 2015-01-06T17:25:51Z | - |
dc.date.available | 2015-01-06T17:25:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0001-6268 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99965 | - |
dc.description.abstract | BACKGROUND: Spinal cord injury (SCI) is a devastating and irreversible event, and much research using fibroblast growth factor-2 (FGF-2) has been performed to test its capacity to blunt the effects of SCI as well as to provide an environment conducive for SCI repair. METHODS: We tested how the in vitro release of FGF-2 from heparin-conjugated poly(L-lactide-co-glycolide) (PLGA)-conjugated nanospheres (HCPNs) affected the growth of human bone marrow-derived mesenchymal stem cells (hBMSCs), as well as the effects of their co-transplantation in an animal model of SCI. RESULTS: Our results showed that sustained, long-term release of FGF-2 from HCPNs significantly increased hBMSCs proliferation in vitro, and that their co-transplantation following rat SCI lead to increased functional improvement, a greater amount of hBMSCs surviving transplantation, and a greater density of neurofilament-positive cells in the injury epicenter. CONCLUSION: These results suggest a proliferative, protective, and neural inductive potential of FGF-2 for transplanted hBMSCs, as well as a possible role for sustained FGF-2 delivery along with hBMSCs transplantation in the injured spinal cord. Future studies will be required to ascertain the safety FGF-2-containing HCPNs before clinical application. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 297~303 | - |
dc.relation.isPartOf | ACTA NEUROCHIRURGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Marrow Cells/cytology* | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Fibroblast Growth Factor 2/pharmacology* | - |
dc.subject.MESH | Mesenchymal Stromal Cells/cytology* | - |
dc.subject.MESH | Nanospheres/administration & dosage* | - |
dc.subject.MESH | Nerve Regeneration/drug effects | - |
dc.subject.MESH | Nerve Regeneration/physiology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recovery of Function/drug effects | - |
dc.subject.MESH | Spinal Cord Injuries/surgery | - |
dc.subject.MESH | Spinal Cord Injuries/therapy* | - |
dc.title | Co-transplantation of bone marrow-derived mesenchymal stem cells and nanospheres containing FGF-2 improve cell survival and neurological function in the injured rat spinal cord | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Dong Ah Shin | - |
dc.contributor.googleauthor | William A. Pennant | - |
dc.contributor.googleauthor | Do Heum Yoon | - |
dc.contributor.googleauthor | Yoon Ha | - |
dc.contributor.googleauthor | Keung Nyun Kim | - |
dc.identifier.doi | 10.1007/s00701-013-1963-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00331 | - |
dc.contributor.localId | A02092 | - |
dc.contributor.localId | A02546 | - |
dc.contributor.localId | A04255 | - |
dc.relation.journalcode | J00018 | - |
dc.identifier.eissn | 0942-0940 | - |
dc.identifier.pmid | 24352373 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00701-013-1963-y | - |
dc.subject.keyword | Bone marrow | - |
dc.subject.keyword | Mesenchymal stem cells | - |
dc.subject.keyword | Nanosphere | - |
dc.subject.keyword | FGF-2 | - |
dc.subject.keyword | Spinal cord injury | - |
dc.contributor.alternativeName | Kim, Keung Nyun | - |
dc.contributor.alternativeName | Shin, Dong A | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.alternativeName | Ha, Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Keung Nyun | - |
dc.contributor.affiliatedAuthor | Shin, Dong A | - |
dc.contributor.affiliatedAuthor | Yoon, Do Heum | - |
dc.contributor.affiliatedAuthor | Ha, Yoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 156 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 297 | - |
dc.citation.endPage | 303 | - |
dc.identifier.bibliographicCitation | ACTA NEUROCHIRURGICA, Vol.156(2) : 297-303, 2014 | - |
dc.identifier.rimsid | 54373 | - |
dc.type.rims | ART | - |
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