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Co-transplantation of bone marrow-derived mesenchymal stem cells and nanospheres containing FGF-2 improve cell survival and neurological function in the injured rat spinal cord

DC Field Value Language
dc.contributor.author김긍년-
dc.contributor.author신동아-
dc.contributor.author윤도흠-
dc.contributor.author하윤-
dc.date.accessioned2015-01-06T17:25:51Z-
dc.date.available2015-01-06T17:25:51Z-
dc.date.issued2014-
dc.identifier.issn0001-6268-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99965-
dc.description.abstractBACKGROUND: Spinal cord injury (SCI) is a devastating and irreversible event, and much research using fibroblast growth factor-2 (FGF-2) has been performed to test its capacity to blunt the effects of SCI as well as to provide an environment conducive for SCI repair. METHODS: We tested how the in vitro release of FGF-2 from heparin-conjugated poly(L-lactide-co-glycolide) (PLGA)-conjugated nanospheres (HCPNs) affected the growth of human bone marrow-derived mesenchymal stem cells (hBMSCs), as well as the effects of their co-transplantation in an animal model of SCI. RESULTS: Our results showed that sustained, long-term release of FGF-2 from HCPNs significantly increased hBMSCs proliferation in vitro, and that their co-transplantation following rat SCI lead to increased functional improvement, a greater amount of hBMSCs surviving transplantation, and a greater density of neurofilament-positive cells in the injury epicenter. CONCLUSION: These results suggest a proliferative, protective, and neural inductive potential of FGF-2 for transplanted hBMSCs, as well as a possible role for sustained FGF-2 delivery along with hBMSCs transplantation in the injured spinal cord. Future studies will be required to ascertain the safety FGF-2-containing HCPNs before clinical application.-
dc.description.statementOfResponsibilityopen-
dc.format.extent297~303-
dc.relation.isPartOfACTA NEUROCHIRURGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBone Marrow Cells/cytology*-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFibroblast Growth Factor 2/pharmacology*-
dc.subject.MESHMesenchymal Stromal Cells/cytology*-
dc.subject.MESHNanospheres/administration & dosage*-
dc.subject.MESHNerve Regeneration/drug effects-
dc.subject.MESHNerve Regeneration/physiology-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHRecovery of Function/drug effects-
dc.subject.MESHSpinal Cord Injuries/surgery-
dc.subject.MESHSpinal Cord Injuries/therapy*-
dc.titleCo-transplantation of bone marrow-derived mesenchymal stem cells and nanospheres containing FGF-2 improve cell survival and neurological function in the injured rat spinal cord-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorDong Ah Shin-
dc.contributor.googleauthorWilliam A. Pennant-
dc.contributor.googleauthorDo Heum Yoon-
dc.contributor.googleauthorYoon Ha-
dc.contributor.googleauthorKeung Nyun Kim-
dc.identifier.doi10.1007/s00701-013-1963-y-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00331-
dc.contributor.localIdA02092-
dc.contributor.localIdA02546-
dc.contributor.localIdA04255-
dc.relation.journalcodeJ00018-
dc.identifier.eissn0942-0940-
dc.identifier.pmid24352373-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00701-013-1963-y-
dc.subject.keywordBone marrow-
dc.subject.keywordMesenchymal stem cells-
dc.subject.keywordNanosphere-
dc.subject.keywordFGF-2-
dc.subject.keywordSpinal cord injury-
dc.contributor.alternativeNameKim, Keung Nyun-
dc.contributor.alternativeNameShin, Dong A-
dc.contributor.alternativeNameYoon, Do Heum-
dc.contributor.alternativeNameHa, Yoon-
dc.contributor.affiliatedAuthorKim, Keung Nyun-
dc.contributor.affiliatedAuthorShin, Dong A-
dc.contributor.affiliatedAuthorYoon, Do Heum-
dc.contributor.affiliatedAuthorHa, Yoon-
dc.rights.accessRightsfree-
dc.citation.volume156-
dc.citation.number2-
dc.citation.startPage297-
dc.citation.endPage303-
dc.identifier.bibliographicCitationACTA NEUROCHIRURGICA, Vol.156(2) : 297-303, 2014-
dc.identifier.rimsid54373-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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