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RhD 불일치 간이식 환자에서 동종면역 방지를 위한 고용량Rh 면역글로불린의 사용
DC Field | Value | Language |
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dc.contributor.author | 김순일 | - |
dc.contributor.author | 김신영 | - |
dc.contributor.author | 김현옥 | - |
dc.contributor.author | 최승준 | - |
dc.date.accessioned | 2015-01-06T17:24:32Z | - |
dc.date.available | 2015-01-06T17:24:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2093-6338 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99923 | - |
dc.description.abstract | Approximately 80-85% of D-negative (D-) persons produce anti-D antibodies after exposure to D-positive (D+) red blood cells (RBCs). Previously, anti-D was the most commonly detected Rh antibody, but its incidence has greatly decreased due to the prophylactic use of Rh immunoglobulin (RhIG). Anti-D antibody formation may occur following RhD-incompatible organ transplantation when D- recipients are exposed to D+ RBCs that originate from a donor organ. As a large volume of donor blood may be contained within the transplanted organ, the use of a large amount of RhIG is required in RhD-incompatible liver transplantation. Here, we describe the use of a large amount of RhIG to treat a patient following RhD-incompatible liver transplantation. This patient was a 71-yr-old woman with hepatitis C virus-related liver cirrhosis, who had an A/D- blood type. The donor was her grandson, whose blood type was O/D+. The recipient's preoperative anti-D antibody test was negative. One unit of O/D- irradiated leukoreduced RBCs and three units of A/D- fresh frozen plasma were transfused during liver transplantation. An equal amount (12,000 IU) of RhIG was infused intravenously, immediately after liver transplantation and a second time on post-operation day 1. The anti-D titer was 1:64 on the first post-operation day, and had increased to 1:128 by the following day. By 1 month after the surgery, the titer had decreased to 1:4. In this case of liver transplantation, RhIG was actively used to prevent RhD sensitization and the subsequent occurrence of adverse events associated with RhD-incompatible liver transplantation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | Laboratory Medicine Online | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | RhD 불일치 간이식 환자에서 동종면역 방지를 위한 고용량Rh 면역글로불린의 사용 | - |
dc.title.alternative | The Use of High-dose Rh Immunoglobulin for the Prevention of D Sensitization in RhDincompatible Liver Transplantation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 박정래 | - |
dc.contributor.googleauthor | 김신영 | - |
dc.contributor.googleauthor | 최승준 | - |
dc.contributor.googleauthor | 송성욱 | - |
dc.contributor.googleauthor | 김현옥 | - |
dc.contributor.googleauthor | 김순일 | - |
dc.identifier.doi | 10.3343/lmo.2014.4.3.168 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00675 | - |
dc.contributor.localId | A01122 | - |
dc.relation.journalcode | J02151 | - |
dc.subject.keyword | RhD sensitization | - |
dc.subject.keyword | Rh immunoglobulin | - |
dc.subject.keyword | Liver transplantation | - |
dc.contributor.alternativeName | Kim, Soon Il | - |
dc.contributor.alternativeName | Kim, Sin Young | - |
dc.contributor.alternativeName | Kim, Hyun Ok | - |
dc.contributor.affiliatedAuthor | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Sin Young | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ok | - |
dc.citation.volume | 4 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 168 | - |
dc.citation.endPage | 171 | - |
dc.identifier.bibliographicCitation | Laboratory Medicine Online, Vol.4(3) : 168-171, 2014 | - |
dc.identifier.rimsid | 53889 | - |
dc.type.rims | ART | - |
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