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Differences in Clinical Manifestations and Outcomes between Adult and Child Patients with Henoch-Schonlein Purpura

 Yoon Kang  ;  Jin-su Park  ;  You-Jung Ha  ;  Mi-il Kang  ;  Hee-Jin Park  ;  Sang-Won Lee  ;  Soo-Kon Lee  ;  Yong-Beom Park 
 Journal of Korean Medical Science, Vol.29(2) : 198-203, 2014 
Journal Title
 Journal of Korean Medical Science 
Issue Date
We aimed to investigate differences in clinical manifestations and outcomes between adult and child patients with Henoch-Schönlein purpura (HSP), and to analyze the factors associated with poor prognosis for HSP nephritis. This retrospective 10-yr study enrolled 160 patients with HSP who visited Severance Hospital. Purpura was mostly detected in lower extremities, but purpura in upper extremities was more frequently observed in adults than children (41.7% vs 19.3%). Children had a greater frequency of arthralgia (55.4% vs 27.1%), while adults had a greater frequency of diarrhea (20% vs 1.6%). Anemia, elevated C-reactive protein, and level of IgA were more frequently observed in adults (25% vs 7.1%, 65.6% vs 38.4%, 26.3% vs 3.5%). Renal involvement in adults was more severe than in children (79.2% vs 30.4%). Chronic renal failure showed a significant difference in outcomes of HSP between adults (10.4%) and children (1.8%) after a follow up period of an average of 27 months. Furthermore, renal insufficiency at diagnosis was significantly related to the progression to chronic renal failure. Our results showed several differences in the clinical features of HSP between adults and children. Adults with HSP had a higher frequency of renal insufficiency and worse renal outcomes than children. Renal insufficiency at diagnosis might be of predictive value for the progression to chronic renal failure in HSP patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강미일(Kang, Mi Il)
강윤(Kang, Yoon)
박용범(Park, Yong Beom)
박진수(Park, Jin Su)
박희진(Park, Hee Jin)
이상원(Lee, Sang Won) ORCID logo https://orcid.org/0000-0002-8038-3341
이수곤(Lee, Soo Kon)
하유정(Ha, You Jung)
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