Cited 31 times in
Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2015-01-06T17:23:44Z | - |
dc.date.available | 2015-01-06T17:23:44Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99898 | - |
dc.description.abstract | Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8±14.4 vs. 22.2±6.1 ng/mL; P<0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ=0.671; γ=0.612; and γ=0.601, P<0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28≥2.6) were significantly higher than those in remission (DAS28<2.6) (36.45±14.36 vs. 24.63±8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1199~1204 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Arthritis, Rheumatoid/blood | - |
dc.subject.MESH | Arthritis, Rheumatoid/diagnosis* | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Blood Sedimentation | - |
dc.subject.MESH | C-Reactive Protein/analysis | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycoproteins/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Severity of Illness Index* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/blood | - |
dc.title | Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | You Jung Ha | - |
dc.contributor.googleauthor | Eun-Jin Kang | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Soo-Kon Lee | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Jung-Soo Song | - |
dc.contributor.googleauthor | Sang Tae Choi | - |
dc.identifier.doi | 10.3346/jkms.2014.29.9.1199 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02889 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 25246736 | - |
dc.subject.keyword | Arthritis, Rheumatoid | - |
dc.subject.keyword | Disease Activity | - |
dc.subject.keyword | Leucine-Rich Alpha-2-Glycoprotein | - |
dc.subject.keyword | Tumor Necrosis Factor-alpha | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.citation.volume | 29 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1199 | - |
dc.citation.endPage | 1204 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.29(9) : 1199-1204, 2014 | - |
dc.identifier.rimsid | 53871 | - |
dc.type.rims | ART | - |
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