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Magnetic Nanoclusters Engineered by Polymer-Controlled Self-Assembly for the Accurate Diagnosis of Atherosclerotic Plaques via Magnetic Resonance Imaging

Authors
 Myeong-Hoon Kim  ;  Bongjune Kim  ;  Eun-Kyung Lim  ;  Yuna Choi  ;  Jihye Choi  ;  Eunjung Kim  ;  Eunji Jang  ;  Hyo Seon Park  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 MACROMOLECULAR BIOSCIENCE, Vol.14(7) : 943-952, 2014 
Journal Title
MACROMOLECULAR BIOSCIENCE
ISSN
 1616-5187 
Issue Date
2014
MeSH
Animals ; Cell Line ; Cell Survival ; Dextrans/chemistry ; Fluorescence ; Hydrodynamics ; Macrophages/ultrastructure ; Magnetic Resonance Imaging* ; Magnetite Nanoparticles/chemistry* ; Magnetite Nanoparticles/ultrastructure ; Male ; Mice ; Nanotechnology/methods* ; Oleic Acid/chemistry ; Particle Size ; Plaque, Atherosclerotic/diagnosis* ; Polymers/chemistry* ; Rats, Sprague-Dawley ; Thermogravimetry ; X-Ray Diffraction
Keywords
atherosclerotic plaque ; dextran ; imaging ; magnetic nanoclusters ; self-assembly
Abstract
Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to provide not only hydrophilicity but also a high affinity to macrophages. Enhanced magnetism of the ODMCs is engineered by optimizing the degree of substitution (DS) of the oleyl group in ODex and the concentration of ODex used for the synthesis of ODMC. Consequently, ODMCs exhibit significantly increased T2 relaxivity and excellent macrophage-targeting ability without cytotoxicity, in vitro. Moreover, in vivo T2-weighted MR imaging after intravenous injection of ODMCs into a rat artery balloon injury model demonstrates considerable MR contrast strength efficacy in the plaques of the injured carotid artery. These novel ODMCs may offer a highly efficient MR imaging nanoprobes for the selective diagnosis of atherosclerosis.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201400029/abstract
DOI
10.1002/mabi.201400029
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99872
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