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Mucosal Healing Predicts the Long-Term Prognosis of Intestinal Behçet’s Disease

DC Field Value Language
dc.contributor.author김덕환-
dc.contributor.author김원호-
dc.contributor.author김태일-
dc.contributor.author박수정-
dc.contributor.author이현정-
dc.contributor.author임선미-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.date.accessioned2015-01-06T17:21:21Z-
dc.date.available2015-01-06T17:21:21Z-
dc.date.issued2014-
dc.identifier.issn0163-2116-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99824-
dc.description.abstractBACKGROUND: Mucosal healing (MH) has emerged as a therapeutic goal in the treatment of inflammatory bowel disease; however, little is known about the impact of MH on the prognosis of intestinal Behçet's disease (BD). AIM: We investigated whether MH could predict the prognosis of intestinal BD. METHODS: We retrospectively reviewed the medical records of 80 patients with intestinal BD who underwent colonoscopy within 3 months after clinical remission. The clinical recurrence rate according to the presence or absence of MH was evaluated using the Kaplan-Meier method and the log-rank test. In order to evaluate MH as an independent prognostic factor, a multivariate analysis using Cox proportional hazards regression model was performed including other potential factors for the relapse of intestinal BD. RESULTS: The number of patients with active ulcers at the time of clinical remission was 57 (71.3%), while 23 patients (28.7%) were experiencing MH. In the active ulcer group, 39 patients (68.4%) experienced recurrence during the follow-up period, whereas 7 patients (30.4%) recurred in the MH group. The cumulative recurrence rate was significantly higher in the active ulcer group than in the MH group (P < 0.001). A multivariate analysis identified active ulcers at the time of clinical remission as an independent predictive factor for relapse. CONCLUSION: Our study demonstrates that MH is an independent factor predictive of long-term prognosis of intestinal BD. MH might be the ultimate therapeutic goal in the treatment of intestinal BD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2529~2535-
dc.relation.isPartOfDIGESTIVE DISEASES AND SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBehcet Syndrome/pathology*-
dc.subject.MESHBehcet Syndrome/therapy*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.subject.MESHYoung Adult-
dc.titleMucosal Healing Predicts the Long-Term Prognosis of Intestinal Behçet’s Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSun Mie Yim-
dc.contributor.googleauthorDuk Hwan Kim-
dc.contributor.googleauthorHyun Jung Lee-
dc.contributor.googleauthorHui Won Jang-
dc.contributor.googleauthorSoo Jung Park-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi10.1007/s10620-014-3198-z-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00377-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA03368-
dc.contributor.localIdA04404-
dc.contributor.localIdA04030-
dc.contributor.localIdA03295-
dc.contributor.localIdA01539-
dc.relation.journalcodeJ00737-
dc.identifier.eissn1573-2568-
dc.identifier.pmid24838499-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10620-014-3198-z-
dc.subject.keywordIntestinal Behçet’s disease-
dc.subject.keywordMucosal healing-
dc.subject.keywordInflammatory bowel disease-
dc.contributor.alternativeNameKim, Duk Hwan-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Soo Jung-
dc.contributor.alternativeNameLee, Hyun Jung-
dc.contributor.alternativeNameYim, Sun Mie-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Duk Hwan-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorYim, Sun Mie-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.contributor.affiliatedAuthorLee, Hyun Jung-
dc.contributor.affiliatedAuthorPark, Soo Jung-
dc.rights.accessRightsfree-
dc.citation.volume59-
dc.citation.number10-
dc.citation.startPage2529-
dc.citation.endPage2535-
dc.identifier.bibliographicCitationDIGESTIVE DISEASES AND SCIENCES, Vol.59(10) : 2529-2535, 2014-
dc.identifier.rimsid49627-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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